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胆囊癌肉瘤:一例报告并文献复习

Carcinosarcoma of the gallbladder: a case report and review of the literature.

作者信息

Gao Shengqiang, Huang Lidong, Dai Shuang, Chen Dongdong, Dai Ruijie, Shan Yunfeng

机构信息

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000, Zhejiang, P.R. China.

Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000, Zhejiang, P.R. China.

出版信息

Int J Clin Exp Pathol. 2015 Jun 1;8(6):7464-9. eCollection 2015.

Abstract

Carcinosarcoma of the gallbladder is a rare malignancy characterized by malignant epithelial and mesenchymal components. The disease usually presents at an advanced stage, and as a result, curative resection is uncommon. This report describes a case that underwent curative resection. We herein declare the case of a patient in a 62-year-old male, with carcinosarcoma of the gallbladder with chondroid differentiation. The patient is treated by a simple cholecystectomy, a wedge resection of the underlying liver tissue and the pericholedochal lymph nodes for a tumor which occupied the entire gallbladder. Histologically, the epithelial component of the tumor was composed of adenocarcinoma and the mesenchymal component was composed of fibrosarcoma. The tumor was identified as extend to the serosa tissue and to have metastasized to no lymph node. The prognosis of carcinosarcoma of the gallbladder remains poor despite curative resection, and thus, the authors recommend that effort should be made to improve surgical outcomes. The patient survived 13 months and is still alive today.

摘要

胆囊癌肉瘤是一种罕见的恶性肿瘤,其特征为恶性上皮和间充质成分。该病通常在晚期出现,因此,根治性切除并不常见。本报告描述了一例接受根治性切除的病例。在此,我们报告一例62岁男性患者,患有伴有软骨样分化的胆囊癌肉瘤。患者接受了单纯胆囊切除术、楔形切除其下方的肝组织以及肝门周围淋巴结,以切除占据整个胆囊的肿瘤。组织学上,肿瘤的上皮成分由腺癌组成,间充质成分由纤维肉瘤组成。肿瘤被确定已延伸至浆膜组织,且未发生淋巴结转移。尽管进行了根治性切除,胆囊癌肉瘤的预后仍然很差,因此,作者建议应努力改善手术效果。该患者存活了13个月,至今仍然健在。

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