原发性保健中高血压和糖尿病患者的低白蛋白尿症及其与心血管疾病风险的关系。
Low-grade albuminuria and its relationship with cardiovascular disease risk in hypertensive and diabetic patients in primary health care.
机构信息
Departamento de Medicina e Enfermagem, Universidade Federal de Viçosa, Viçosa, MG, Brazil.
Escola Nacional de Saúde Pública. Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.
出版信息
BMC Nephrol. 2022 Jul 20;23(1):257. doi: 10.1186/s12882-022-02884-7.
OBJECTIVE
To evaluate the presence of LGA and the relationship with the 10-year risk of a cardiovascular event in hypertensive and diabetic patients in Primary Health Care.
STUDY DESIGN
The study design used is cross-sectional.
METHODS
This study was based on the application of questionnaires, anthropometric measurements, and laboratory tests carried out from August 2017 to April 2018. Logistic regression was used to evaluate the odds ratio of the explanatory variables in relation to the highest tercile of LGA. The Framingham risk score was used to assess the 10-year risk of cardiovascular event. The comparison of this score with the LGA terciles was analyzed using ANOVA.
RESULTS
An increase in the 10-year risk of cardiovascular event score was observed with an increasing LGA tercile, and this pattern prevailed after adjusting for confounding variables.
CONCLUSION
An association between LGA and the 10-year risk of cardiovascular event was observed in a representative sample of hypertensive and diabetic patients.
目的
评估在初级保健中，高血压和糖尿病患者中巨大儿（LGA）的存在及其与 10 年内心血管事件风险的关系。
研究设计
本研究采用的是横断面研究设计。
方法
本研究基于 2017 年 8 月至 2018 年 4 月期间进行的问卷调查、人体测量和实验室检查。使用逻辑回归评估解释变量与 LGA 最高三分位数的比值比。使用 Framingham 风险评分评估 10 年内心血管事件的风险。使用方差分析（ANOVA）分析该评分与 LGA 三分位数的比较。
结果
随着 LGA 三分位数的增加，观察到 10 年内心血管事件评分的风险增加，并且在调整混杂变量后仍然存在这种模式。
结论
在高血压和糖尿病患者的代表性样本中观察到 LGA 与 10 年内心血管事件风险之间存在关联。
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