Hong Jae Won, Ku Cheol Ryong, Noh Jung Hyun, Ko Kyung Soo, Rhee Byoung Doo, Kim Dong-Jun
Department of Internal Medicine, Ilsan-Paik Hospital, College of Medicine, Inje University, Koyang, Gyeonggi-do, Republic of Korea.
Endocrinology, Yonsei University College of Medicine, Seoul, South Korea.
PLoS One. 2015 Mar 5;10(3):e0118866. doi: 10.1371/journal.pone.0118866. eCollection 2015.
Recent studies have indicated that low UACR levels (<30 μg/mg) previously considered to be in the normal range ('low-grade albuminuria') are associated with cardiovascular morbidity and mortality in the general population.
We studied 9,736 participants with albuminuria in the normal range from the 2011-2012 Korea National Health and Nutrition Examination Survey (KNHANES).
The weighted prevalences of metabolic syndrome (MS) and the 10-year risk for coronary heart disease measured using the Framingham risk score (FRS) ≥ 20% (high risk) were 22.5 ± 0.7% and 14.5 ± 0.7%, respectively, in males and 23.3 ± 0.8% and 8.5 ± 0.4%, respectively in females. Weighted comparisons among the tertiles of UACR revealed that the prevalences of MS and high-risk FRS increased with increasing UACR (MS: males, 15.9 ± 1.1, 20.2 ± 1.2, 32.4 ± 1.5%, respectively; P < 0.001; and females, 17.6 ± 1.0, 22.7 ± 1.0, 30.2 ± 1.4%, respectively; P < 0.001. High-risk FRS: males, 9.5 ± 0.7, 12.3 ± 0.9, 22.5 ± 1.2, respectively; P < 0.001; and females, 5.8 ± 0.6, 7.9 ± 0.7, 12.0 ± 0.9%, respectively; P < 0.001). The positive association persisted after adjusting for hypertension and diabetes. The weighted comparisons among the deciles of UACR revealed that the prevalences of MS and high-risk FRS began to increase at the ranges of 3.89-5.15 and 5.16-7.36 mg/g Cr, respectively.
Low-grade albuminuria was significantly associated with estimated cardiovascular risk and MS in a nationally representative sample of Koreans.
近期研究表明，尿白蛋白肌酐比值（UACR）水平较低（<30μg/mg），此前被认为处于正常范围（“低级别蛋白尿”），与普通人群的心血管发病率和死亡率相关。
我们对来自2011 - 2012年韩国国民健康与营养检查调查（KNHANES）的9736名尿白蛋白处于正常范围的参与者进行了研究。
男性代谢综合征（MS）的加权患病率以及使用弗雷明汉风险评分（FRS）测量的10年冠心病风险≥20%（高风险）分别为22.5±0.7%和14.5±0.7%，女性分别为23.3±0.8%和8.5±0.4%。UACR三分位数之间的加权比较显示，MS和高风险FRS的患病率随UACR升高而增加（MS：男性分别为15.9±1.1%、20.2±1.2%、32.4±1.5%；P<0.001；女性分别为17.6±1.0%、22.7±1.0%、30.2±1.4%；P<0.001。高风险FRS：男性分别为9.5±0.7%、12.3±0.9%、22.5±1.2%；P<0.001；女性分别为5.8±0.6%、7.9±0.7%、12.0±0.9%；P<0.001）。在调整高血压和糖尿病因素后，这种正相关仍然存在。UACR十分位数之间的加权比较显示，MS和高风险FRS的患病率分别在3.89 - 5.15和5.16 - 7.36mg/g Cr范围内开始增加。
在具有全国代表性的韩国样本中，低级别蛋白尿与估计的心血管风险和MS显著相关。
