Bulstrode C J, Goode A W, Scott P J
J R Soc Med. 1987 Apr;80(4):210-2. doi: 10.1177/014107688708000406.
Thirty chronic leg ulcers have been studied under controlled conditions until complete healing occurred. Measurement was performed weekly using a computer-linked stereocamera which is capable of measuring skin defects noninvasively with errors of less than 2%. There was a significant difference in healing rate for the first two weeks between clean ulcers entering the trial directly and ulcers admitted first for cleansing before joining the trial. The difference suggests that the weekly healing rate of an ulcer may take up to 2 weeks to respond to a new form of treatment. Absolute ulcer size, change in ulcer size and rate of epithelial migration did not correlate well with time to complete healing, but percentage change in area in the third week was found to be the parameter which gave the earliest close correlation with time to complete healing. Using this parameter, on the data available it was found that time to complete healing could be predicted to within one week for 50% of the ulcers, making this a simple and useful early predictor of treatment efficiency.
在可控条件下对30例慢性腿部溃疡进行了研究，直至溃疡完全愈合。每周使用一台与计算机相连的立体相机进行测量，该相机能够无创测量皮肤缺损，误差小于2%。直接进入试验的清洁溃疡与先入院进行清创再加入试验的溃疡在前两周的愈合率存在显著差异。这种差异表明，溃疡的每周愈合率可能需要长达2周的时间才能对新的治疗方式做出反应。溃疡的绝对大小、溃疡大小的变化以及上皮迁移率与完全愈合的时间相关性不佳，但发现第三周面积的百分比变化是与完全愈合时间最早密切相关的参数。利用这一参数，根据现有数据发现，50%的溃疡完全愈合的时间可以预测在一周内，这使得它成为一种简单而有用的治疗效果早期预测指标。
