Department of Pediatric and Preventive Dentistry, I.T.S Dental College, Ghaziabad, Uttar Pradesh, India.
Department of Oral and Maxillofacial Pathology and Microbiology, I.T.S Dental College, Ghaziabad, Uttar Pradesh, India.
J Indian Soc Pedod Prev Dent. 2022 Apr-Jun;40(2):124-131. doi: 10.4103/jisppd.jisppd_76_22.
Dental caries being the leading health issue worldwide has no specific cure due to its multifactorial etiology and genetic susceptibility. Hence, this paper attempted to correlate the clinical and hereditary factors between mother and child, to predict the caries occurrence in child in future, and thereby implement early preventive measures.
The aim of the study was to look for an association between maternal and child's human leukocyte antigen (HLA)-DR4 levels and relate it with other physiochemical factors to assess caries susceptibility in children.
Saliva samples were collected from children who were in the age group of 0-6 years and their mothers by spitting method and swab method. The clinical indicators such as Decayed, Missing, and Filled Teeth, decayed, extraction needed, and filled teeth, salivary flow rate, and pH were recorded by clinical evaluation. The Streptococcus mutans count was measured by culture plate followed by colony count method, and the HLA-DR4 factor was assessed using ELISA.
The results revealed a statistically significant correlation between the physiochemical factors of the mother and the child. The genetic factor in which the HLA-DR4 caries indicator was checked also has a strong association between the mother and the offspring. Thus, a strong caries prediction formula was derived through which probability of caries occurrence in the child could be determined prematurely.
Thus, it can be concluded that using the clinical and genetic factors, the caries prediction can be done for the child and preventive protocol can be started before disease occurrence.
由于龋齿的多因素病因和遗传易感性，它是全球领先的健康问题，目前尚无特定的治疗方法。因此，本文试图在母子之间关联临床和遗传因素，以预测儿童未来的龋齿发生，并因此实施早期预防措施。
本研究旨在寻找母亲和儿童人类白细胞抗原（HLA）-DR4 水平之间的关联，并将其与其他生理化学因素相关联，以评估儿童的龋齿易感性。
通过吐口水法和拭子法收集 0-6 岁儿童及其母亲的唾液样本。通过临床评估记录临床指标，如龋齿、缺失和填充的牙齿、龋齿、需要拔除和填充的牙齿、唾液流量和 pH 值。通过培养平板和菌落计数法测量变形链球菌计数，使用 ELISA 评估 HLA-DR4 因子。
结果显示母亲和孩子的生理化学因素之间存在统计学显著相关性。检查 HLA-DR4 龋齿指标的遗传因素与母亲和后代之间也有很强的关联。因此，通过该关联可以得出一个强有力的龋齿预测公式，从而可以提前确定孩子患龋齿的概率。
因此，可以得出结论，使用临床和遗传因素可以对儿童进行龋齿预测，并在疾病发生之前开始预防方案。
