Quraishi Rizwana, Varshney Mohit, Rao Ravindra V, Ambekar Atul
Department of Psychiatry, National Drug Dependence Treatment Center, All India Institute of Medical Sciences, Delhi, India.
Department of Psychiatry, Institute of Liver and Biliary Sciences, Vasant Kunj, New Delhi, India.
Indian J Psychiatry. 2022 May-Jun;64(3):312-315. doi: 10.4103/indianjpsychiatry.indianjpsychiatry_88_22. Epub 2022 Jun 8.
Opioid-dependent patients undergoing opioid substitution therapy (OST) consume alcohol in a hazardous pattern which adversely affects their treatment outcome. This study aims to measure alcohol biomarkers to screen for secondary alcohol use in OST patients.
A pilot study was planned to measure alcohol biomarkers (AST, ALT, GGT, and CDT) to assess alcohol use in OST patients from three community clinics. The biomarkers were categorized based on the reported frequency of alcohol use. The association of the biomarkers with the frequency of alcohol consumption was determined using the (Mann-Whitney) test.
Forty-five patients with a mean (SD) age of 37.04 (10.7) years were included in the study. Alcohol intake was reported in daily, weekly, and monthly patterns by 22, 63, and 16% of the patients, respectively. High levels of ALT, GGT, and CDT were measured in patients with daily use of alcohol. Serum CDT levels significantly differentiate daily and weekly use from monthly consumption of alcohol.
Alcohol biomarkers significantly predict the pattern of alcohol use among OST patients. These results can be prudent in low-resource community clinics to improve the overall outcomes of OST in India.
接受阿片类药物替代疗法（OST）的阿片类药物依赖患者存在有害饮酒模式，这对他们的治疗结果产生不利影响。本研究旨在测量酒精生物标志物，以筛查OST患者中的继发性饮酒情况。
计划开展一项试点研究，测量酒精生物标志物（谷草转氨酶、谷丙转氨酶、γ-谷氨酰转肽酶和平均红细胞体积分布宽度），以评估来自三家社区诊所的OST患者的饮酒情况。根据报告的饮酒频率对生物标志物进行分类。使用曼-惠特尼检验确定生物标志物与饮酒频率之间的关联。
45名平均（标准差）年龄为37.04（10.7）岁的患者纳入研究。分别有22%、63%和16%的患者报告每日、每周和每月饮酒。每日饮酒的患者谷丙转氨酶、γ-谷氨酰转肽酶和平均红细胞体积分布宽度水平较高。血清平均红细胞体积分布宽度水平显著区分每日和每周饮酒与每月饮酒情况。
酒精生物标志物可显著预测OST患者的饮酒模式。这些结果对于资源匮乏的社区诊所可能是审慎的，以改善印度OST的总体结果。
