Lei Li, Meng Li, Changqing Xu, Chen Zhu, Gang Yao, Shiyuan Fang
Department of Orthopaedics, The First Affiliated Hospital of University of Science and Technology of China, 17 Lujiang Road, Hefei, Anhui, China.
Department of Orthopaedics, Dongxihu District People's Hospital Affiliated to Huazhong University of Science and Technology, Wuhan, China.
Open Life Sci. 2022 Jul 7;17(1):695-709. doi: 10.1515/biol-2022-0075. eCollection 2022.
Osteoarthritis (OA) is a chronic arthritic disease characterized by cartilage degradation, synovial inflammation, and subchondral bone lesions. The studies on the pathogenesis of OA are complex and diverse. The roles of receptors signaling in chondrocyte anabolism, inflammatory factors expression of synovial fibroblast, and angiogenesis in subchondral bone are particularly important for exploring the pathological mechanism of OA and clinical diagnosis and treatment. By reviewing the relevant literature, this article elaborates on the abnormal expression of receptors and the signaling transduction pathways from different pathological changes of OA anatomical components, aiming to provide new research ideas and clinical therapeutic value for OA pathogenesis.
骨关节炎（OA）是一种慢性关节炎疾病，其特征为软骨降解、滑膜炎症和软骨下骨病变。关于OA发病机制的研究复杂多样。受体信号在软骨细胞合成代谢、滑膜成纤维细胞炎症因子表达以及软骨下骨血管生成中的作用，对于探索OA的病理机制及临床诊断和治疗尤为重要。通过回顾相关文献，本文从OA解剖成分的不同病理变化阐述了受体的异常表达及信号转导通路，旨在为OA发病机制提供新的研究思路及临床治疗价值。
