Lu Xiaomeng, Qi Ce, Zheng Jie, Sun Mei, Jin Long, Sun Jin
Institute of Nutrition and Health, Qingdao University, Qingdao, China.
National R&D Center for Nuts Processing Technology, Qiaqia Food Co., Ltd., Hefei, China.
Front Nutr. 2022 Jul 1;9:908297. doi: 10.3389/fnut.2022.908297. eCollection 2022.
Sunflower seeds provide tryptophan-rich proteins with the potential to protect against depression. Tryptophan is a precursor of serotonin and a substrate for the production of indole derivatives by gut microbiota. This study aimed to investigate the association between the depression-alleviating effects of deoiled and dechlorogenic sunflower seeds (DSFS) and regulation of gut microbiota.
Male C57BL/6J mice were fed a diet comprising a source of soy protein (normal and model control), DSFS or whey protein concentrate (positive control) for 7 weeks, and chronic stress-induced depression was induced.
Feeding the DSFS diet prevented depression-like behaviors, intestinal barrier damage, elevated plasma corticosterone, and reduced hippocampal serotonin levels in mice. Meanwhile, Feeding the DSFS diet significantly altered the gut microbiota structure, characterized by elevated relative abundances of , , , and , which were inversely associated with depressive behaviors and markers of mucosal barrier damage. DSFS also altered the gut metabolite profile, prevented depression-induced gut L-tryptophan depletion, and upregulated its metabolite indoleacetaldehyde.
Feeding the DSFS diet prevented depression in mice by remodeling the gut microbiota and bacterial tryptophan metabolism.
葵花籽富含色氨酸的蛋白质具有预防抑郁症的潜力。色氨酸是血清素的前体，也是肠道微生物群产生吲哚衍生物的底物。本研究旨在探讨脱油脱绿原酸葵花籽（DSFS）的抗抑郁作用与肠道微生物群调节之间的关联。
雄性C57BL/6J小鼠喂食含大豆蛋白来源（正常和模型对照）、DSFS或乳清蛋白浓缩物（阳性对照）的饮食7周，并诱导慢性应激性抑郁症。
喂食DSFS饮食可预防小鼠出现抑郁样行为、肠道屏障损伤、血浆皮质酮升高以及海马体血清素水平降低。同时，喂食DSFS饮食显著改变了肠道微生物群结构，其特征是 、 、 和 的相对丰度升高，这些与抑郁行为和黏膜屏障损伤标志物呈负相关。DSFS还改变了肠道代谢物谱，预防了抑郁症诱导的肠道L-色氨酸耗竭，并上调了其代谢物吲哚乙醛。
喂食DSFS饮食通过重塑肠道微生物群和细菌色氨酸代谢来预防小鼠抑郁症。
