毛蕊花糖苷的热降解动力学和pH-速率曲线以及固体脂质纳米粒对其稳定性的改善
Thermal Degradation Kinetics and pH-Rate Profile of Verbascoside and Stability Improvement by Solid Lipid Nanoparticles.
作者信息
Wisuitiprot Vanuchawan, Ingkaninan Kornkanok, Chakkavittumrong Panlop, Wisuitiprot Wudtichai, Wongwad Eakkaluk, Waranuch Neti
机构信息
Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok 65000, Thailand.
Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand.
出版信息
ACS Med Chem Lett. 2022 Jun 21;13(7):1191-1197. doi: 10.1021/acsmedchemlett.2c00145. eCollection 2022 Jul 14.
Thermal degradation of verbascoside (VB) in Vahl (AE) always affects its health benefit. Here the temperature effect on VB in both AE extract and solid lipid nanoparticles (SLNs)-encapsulated AE extract was demonstrated using the Arrhenius plot. The reaction rate constants were calculated for shelf life and plotted to obtain pH-rate profiles. VB degradation was a first-order reaction. The reaction rate in a neutral to alkaline solution was faster than in an acidic solution. VB in AE extract-loaded SLNs was more stable than in uncapped AE extract. The shelf life of VB in SLNs was 153 days with activation energy ( ) of 76.16 kJ mol, whereas those of VB in AE extract and in AE extract solution were 75 days with = 78.03 kJ mol and 12 days with = 49.24 kJ mol, respectively. Therefore, we anticipate that the AE extract-loaded SLNs will be beneficial for product development.
毛蕊花糖苷（VB）在毛蕊花（AE）中的热降解总是会影响其健康益处。在此，利用阿累尼乌斯图证明了温度对AE提取物和固体脂质纳米粒（SLNs）包封的AE提取物中VB的影响。计算了保质期的反应速率常数，并绘制曲线以获得pH-速率曲线。VB降解为一级反应。中性至碱性溶液中的反应速率比酸性溶液中快。负载AE提取物的SLNs中的VB比未包封的AE提取物中的VB更稳定。SLNs中VB的保质期为153天，活化能（）为76.16 kJ/mol，而AE提取物和AE提取物溶液中VB的保质期分别为75天（= 78.03 kJ/mol）和12天（= 49.24 kJ/mol）。因此，我们预计负载AE提取物的SLNs将有利于产品开发。
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