RNA N-甲基腺嘌呤修饰、细胞重编程与癌症干性
RNA N-Methyladenine Modification, Cellular Reprogramming, and Cancer Stemness.
作者信息
Chen Huarong, Wang Yifei, Su Hao, Zhang Xiaoting, Chen Hongyan, Yu Jun
机构信息
Department of Anaesthesia and Intensive Care and Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong Kong, China.
Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China.
出版信息
Front Cell Dev Biol. 2022 Jul 4;10:935224. doi: 10.3389/fcell.2022.935224. eCollection 2022.
N-Methyladenosine (mA) is the most abundant modification on eukaryote messenger RNA and plays a key role in posttranscriptional regulation of RNA metabolism including splicing, intracellular transport, degradation, and translation. mA is dynamically regulated by methyltransferases (writers), RNA-binding proteins (readers), and demethylases (erasers). Recent studies demonstrate that perturbation of mA regulators remarkably influences cell fate transitions through rewiring various biological processes, such as growth, differentiation, and survival. Moreover, aberrant mA modification is implicated in a variety of diseases, in particular cancer. In this review, we describe the functional linkage of mA modifications to cellular reprogramming and cancer stemness properties.
N-甲基腺苷（mA）是真核生物信使RNA上最丰富的修饰，在RNA代谢的转录后调控中起关键作用，包括剪接、细胞内运输、降解和翻译。mA由甲基转移酶（写入器）、RNA结合蛋白（读取器）和去甲基酶（擦除器）动态调控。最近的研究表明，mA调节因子的扰动通过重新连接各种生物学过程，如生长、分化和存活，显著影响细胞命运转变。此外，异常的mA修饰与多种疾病有关，尤其是癌症。在本综述中，我们描述了mA修饰与细胞重编程和癌症干性特性之间的功能联系。
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