The role of Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) as mA readers in cancer.

RNA can be modified by over 170 types of distinct chemical modifications, and the most abundant internal modification of mRNA in eukaryotes is N6-methyladenosine (mA). The mA modification accelerates mRNA process, including mRNA splicing, translation, transcript stability, export and decay. mA RNA modification is installed by methyltransferase-like proteins (writers), and potentially removed by demethylases (erasers), and this process is recognized by mA-binding proteins (readers). Notably, alterations of mA-modified proteins (writers, erasers and readers) are involved in the tumorigenesis, progression and metastasis. Importantly, the fate of mA-methylated mRNA is mediated mostly through mA readers, and among these readers, insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) are unique RNA-binding proteins (RBPs) that stabilize their targets mRNA via mA modification. In this review, we update the writers, erasers and readers, and their cross-talks in mA modification, and briefly discuss the oncogenic role of IGF2BPs in cancer. Most importantly, we mainly review the up-to-date knowledges of IGF2BPs (IGF2BP1/2/3) as mA readers in an mA-modified manner in cancer progression.