Mohd Ghozali Nurulmuna, Giribabu Nelli, Salleh Naguib
Department of Physiology, Faculty of Medicine, University of Malaya, Lembah Pantai, Kuala Lumpur 59100, Malaysia.
Int J Endocrinol. 2022 Jul 6;2022:6453882. doi: 10.1155/2022/6453882. eCollection 2022.
Vitamin D deficiency is a common health problem worldwide. Despite its known skeletal effects, studies have begun to explore its extra-skeletal effects, that is, in preventing metabolic diseases such as obesity, hyperlipidemia, and diabetes mellitus. The mechanisms by which vitamin D deficiency led to these unfavorable metabolic consequences have been explored. Current evidence indicates that the deficiency of vitamin D could impair the pancreatic -cell functions, thus compromising its insulin secretion. Besides, vitamin D deficiency could also exacerbate inflammation, oxidative stress, and apoptosis in the pancreas and many organs, which leads to insulin resistance. Together, these will contribute to impairment in glucose homeostasis. This review summarizes the reported metabolic effects of vitamin D, in order to identify its potential use to prevent and overcome metabolic diseases.
维生素D缺乏是全球常见的健康问题。尽管已知其对骨骼有影响，但研究已开始探索其骨骼外的作用，即预防肥胖、高脂血症和糖尿病等代谢性疾病。维生素D缺乏导致这些不良代谢后果的机制已得到探讨。目前的证据表明，维生素D缺乏会损害胰岛β细胞功能，从而影响胰岛素分泌。此外，维生素D缺乏还会加剧胰腺和许多器官的炎症、氧化应激和细胞凋亡，进而导致胰岛素抵抗。这些共同作用会导致葡萄糖稳态受损。本综述总结了已报道的维生素D的代谢作用，以确定其在预防和克服代谢性疾病方面的潜在用途。
