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一名正在服用钠-葡萄糖协同转运蛋白2抑制剂的急性中风患者发生了正常血糖性糖尿病酮症酸中毒。

Euglycemic diabetic ketoacidosis in a patient with acute stroke taking sodium glucose co-transporter 2 inhibitor.

作者信息

Pathak Bishnu Deep, Dhakal Bishal, Bhattarai Ayush Mohan, Regmi Binit Upadhaya, Mandal Sujit Kumar, Panta Prashanta Raj, Khadka Suman, Simkhada Nabin

机构信息

Nepalese Army Institute of Health Sciences, College of Medicine, Kathmandu, Nepal.

Department of Internal Medicine, Nepalese Army Institute of Health Sciences, College of Medicine, Kathmandu, Nepal.

出版信息

Ann Med Surg (Lond). 2022 Jul 5;79:104118. doi: 10.1016/j.amsu.2022.104118. eCollection 2022 Jul.

Abstract

INTRODUCTION

Diabetic Ketoacidosis is characterized by a triad of metabolic acidosis, hyperglycemia, and ketonemia. It is a medical emergency that needs urgent and aggressive management. In some cases, the blood glucose level may be relatively normal. Such a condition is known as Euglycemic Diabetic Ketoacidosis.

CASE PRESENTATION

We present a case of Euglycemic Diabetic Ketoacidosis, who was initially brought to the emergency room with the features of acute stroke. There was a diagnostic dilemma among the treating physicians due to his relatively normal blood glucose levels while he developed ketoacidosis.

DISCUSSION

Presentation of the patients includes similar to DKA such as nausea, vomiting, malaise, fatigue, and Kussmaul's respiration. The diabetic patients under sodium glucose co-transporter-2 inhibitor therapy may develop it under the setting of different precipitating factors like infection, trauma/surgery, strenuous physical exercise, fasting, alcohol intake and acute vascular events.

CONCLUSION

Euglycemic DKA is a rare condition and its diagnosis is a challenging task. So, we should always consider it as a differential whenever any diabetic patient shows with increased anion gap metabolic acidosis with or without typical symptoms and signs. Also, we need to be aware to discontinue of SGLT-2 medication during the time of infection, surgery, severe trauma, acute illness and dehydration in the diabetic patients.

摘要

引言

糖尿病酮症酸中毒的特征为代谢性酸中毒、高血糖和酮血症三联征。它是一种需要紧急且积极治疗的医疗急症。在某些情况下,血糖水平可能相对正常。这种情况被称为正常血糖性糖尿病酮症酸中毒。

病例报告

我们报告一例正常血糖性糖尿病酮症酸中毒病例,该患者最初因急性中风症状被送至急诊室。由于其在发生酮症酸中毒时血糖水平相对正常,治疗医生面临诊断难题。

讨论

患者的表现与糖尿病酮症酸中毒相似,如恶心、呕吐、不适、疲劳和库斯莫尔呼吸。接受钠-葡萄糖协同转运蛋白2抑制剂治疗的糖尿病患者在不同的诱发因素如感染、创伤/手术、剧烈体育锻炼、禁食、饮酒和急性血管事件等情况下可能会发生该病。

结论

正常血糖性糖尿病酮症酸中毒是一种罕见病症,其诊断具有挑战性。因此,每当任何糖尿病患者出现阴离子间隙代谢性酸中毒且伴有或不伴有典型症状和体征时,我们都应始终将其视为鉴别诊断之一。此外,我们需要注意在糖尿病患者发生感染、手术、严重创伤、急性疾病和脱水时停用钠-葡萄糖协同转运蛋白2药物。

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引用本文的文献

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