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芳樟醇通过调控 AKT/mTOR 和 JAK2/STAT3 信号通路影响结直肠癌恶化。

Linalool Impress Colorectal Cancer Deterioration by Mediating AKT/mTOR and JAK2/STAT3 Signaling Pathways.

机构信息

Department of Oncology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.

Department of Traditional Chinese Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.

出版信息

Biomed Res Int. 2022 Jul 11;2022:4801703. doi: 10.1155/2022/4801703. eCollection 2022.

DOI:10.1155/2022/4801703
PMID:35860797
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9293539/
Abstract

Colorectal cancer (CRC) is one of the more common causes of cancer death worldwide. Chemotherapy is effective in the treatment of CRC, but it can produce a range of adverse effects that can significantly reduce the quality of life of CRC patients. The selection of drugs that are effective in treating CRC with few adverse effects is now an important task and is aimed at prolonging the survival of patients and improving their prognosis. In this study, CRC cells were treated with linalool using CRC cell lines as the study subjects, and cell viability, apoptosis, and cell migration were observed after treatment. Previous studies have demonstrated the therapeutic effects of linalool on CRC and its ability to inhibit CRC progression by modulating the AKT/mTOR and JAK2/STAT3 pathways.

摘要

结直肠癌（CRC）是全球较为常见的癌症死因之一。化疗对 CRC 的治疗有效，但会产生一系列不良反应，显著降低 CRC 患者的生活质量。因此，选择具有较少不良反应的有效药物治疗 CRC 是目前的一项重要任务，旨在延长患者的生存时间并改善其预后。在这项研究中，我们以 CRC 细胞系为研究对象，用芳樟醇处理 CRC 细胞，观察处理后细胞活力、细胞凋亡和细胞迁移的变化。先前的研究表明芳樟醇对 CRC 具有治疗作用，通过调节 AKT/mTOR 和 JAK2/STAT3 通路抑制 CRC 进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fffa/9293539/7e8b80188f7c/BMRI2022-4801703.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fffa/9293539/113e0f2eb6a7/BMRI2022-4801703.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fffa/9293539/b1a7fa200350/BMRI2022-4801703.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fffa/9293539/0a3f2b8f1b20/BMRI2022-4801703.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fffa/9293539/d22840d240a0/BMRI2022-4801703.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fffa/9293539/7e8b80188f7c/BMRI2022-4801703.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fffa/9293539/113e0f2eb6a7/BMRI2022-4801703.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fffa/9293539/b1a7fa200350/BMRI2022-4801703.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fffa/9293539/0a3f2b8f1b20/BMRI2022-4801703.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fffa/9293539/d22840d240a0/BMRI2022-4801703.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fffa/9293539/7e8b80188f7c/BMRI2022-4801703.005.jpg

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Corrigendum: Phytochemicals in Cancer Treatment: From Preclinical Studies to Clinical Practice.
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