Tewfik S A, el-Sawy M M, Abaza M H, Sidrak M S, Mikhail M M, Ziada L E, Shaala I Y
J Trop Med Hyg. 1987 Jun;90(3):143-7.
Simultaneous platelet and fibrinogen survival and turnover were studied using selenomethionine (75Se) in early and late groups of schistosomal hepatic fibrosis (SHF) and in a control group. In the control group, the mean platelet survival was 11.66 +/- 1.59 days and mean platelet turnover was 20,230 +/- 5090 platelets/microliter/day. Mean fibrinogen survival was 7.3 +/- 0.60 days and fibrinogen turnover was 0.35 +/- 0.04 mg/ml/day. In the early schistosomal group, platelet survival was shortened with an increased turnover rate and normal platelet count. The presence of a structurally abnormal fibrinogen molecule in the early group may have resulted in its shortened survival, that was compensated by the liver through increasing the turnover rate. In the late group, platelet survival was shortened with no significant increase of fibrinogen turnover, while fibrinogen concentration remained normal, suggesting the presence of extrahepatic sites of fibrinogen synthesis.
使用硒代蛋氨酸（75Se）对血吸虫性肝纤维化（SHF）的早期和晚期组以及对照组同时进行血小板和纤维蛋白原的存活及周转率研究。在对照组中，平均血小板存活时间为11.66±1.59天，平均血小板周转率为20,230±5090个血小板/微升/天。平均纤维蛋白原存活时间为7.3±0.60天，纤维蛋白原周转率为0.35±0.04毫克/毫升/天。在早期血吸虫组中，血小板存活时间缩短，周转率增加，血小板计数正常。早期组中存在结构异常的纤维蛋白原分子可能导致其存活时间缩短，肝脏通过增加周转率进行了补偿。在晚期组中，血小板存活时间缩短，纤维蛋白原周转率无显著增加，而纤维蛋白原浓度保持正常，提示存在肝外纤维蛋白原合成部位。
