Department of Gastroenterology, General Hospital of Northern Theater Command (formerly General Hospital of Shenyang Military Area), Shenyang, Liaoning, China.
Graduate School, Jinzhou Medical University, Jinzhou, Liaoning, China.
Postgrad Med. 2022 Sep;134(7):668-674. doi: 10.1080/00325481.2022.2105094. Epub 2022 Jul 26.
The doses of medications may influence the success of () eradication. This real-world observational study aimed to explore the impact of insufficient doses of medications prescribed for the bismuth-containing quadruple therapy (BQT) regimen on successful eradication.
We retrospectively screened the patients who were diagnosed with infection and received BQT regimens for eradication at our department between January 2017 and July 2020. The rate of successful eradication was compared according to the doses of medications prescribed. Standard doses were defined according to the clinical guidelines.
Overall, 1054 patients were included. The rate of successful eradication was 78.2% (824/1054). Among them, proton pump inhibitors (PPIs) and antibiotics were prescribed at insufficient doses in 37.0% (390/1054) and 6.7% (71/1054) of patients, respectively. Furthermore, pantoprazole (98.7% [385/390]) was the most common type of PPIs prescribed at insufficient doses, and nitroimidazoles (85.9% [61/71]) were the most common type of antibiotics prescribed at insufficient doses. Among the patients receiving colloidal bismuth pectin (CBP) (200 mg tid) and standard-dose antibiotics, the rate of successful eradication was lower in insufficient-dose PPIs group than standard-dose PPIs group (78.1% [271/347] versus 82.6% [438/530], P = 0.095). Among the patients receiving CBP (200 mg tid) and standard-dose PPIs, the rate of successful eradication was significantly lower in insufficient-dose antibiotics group than standard-dose antibiotics group (37.8% [14/37] versus 82.6% [438/530], P < 0.0001). Among the patients receiving CBP 200 mg tid, the rate of successful eradication was significantly lower in patients receiving both PPIs and antibiotics at insufficient doses than those at standard doses (46.4% [13/28] versus 82.6% [438/530], P < 0.0001).
Among the BQT regimens, PPIs and/or antibiotics, especially pantoprazole and metronidazole, are often prescribed at insufficient doses, compromising the success of eradication.
; UBT, urea breath test; DPM, disintegrations per minute; BQT, bismuth-containing quadruple therapy; PPI, proton pump inhibitor; CBP, colloidal bismuth pectin; qd, once daily; bid, twice daily; tid, three times daily; qid, four times daily.
药物剂量可能会影响 () 根除的成功率。本真实世界观察性研究旨在探讨铋四联疗法（BQT）方案中规定剂量不足的药物对成功根除的影响。
我们回顾性筛选了 2017 年 1 月至 2020 年 7 月在我科诊断为 感染并接受 BQT 方案治疗以根除 的患者。根据所开药物剂量比较成功根除的比例。标准剂量根据临床指南定义。
共有 1054 例患者入选。成功根除的比例为 78.2%（824/1054）。其中，质子泵抑制剂（PPIs）和抗生素的剂量不足分别占 37.0%（390/1054）和 6.7%（71/1054）。此外，最常开出剂量不足的 PPIs 是泮托拉唑（98.7%[385/390]），最常开出剂量不足的抗生素是硝基咪唑类（85.9%[61/71]）。在接受胶体果胶铋（CBP）（200 mg tid）和标准剂量抗生素的患者中，PPIs 剂量不足组的成功根除率低于标准剂量 PPIs 组（78.1%[271/347]与 82.6%[438/530]，P=0.095）。在接受 CBP（200 mg tid）和标准剂量 PPIs 的患者中，抗生素剂量不足组的成功根除率明显低于标准剂量抗生素组（37.8%[14/37]与 82.6%[438/530]，P<0.0001）。在接受 CBP 200 mg tid 的患者中，PPIs 和/或抗生素剂量不足的患者的成功根除率明显低于标准剂量的患者（46.4%[13/28]与 82.6%[438/530]，P<0.0001）。
在 BQT 方案中，PPIs 和/或抗生素，尤其是泮托拉唑和甲硝唑，经常规定剂量不足，从而影响了根除的成功率。
