Gumenyuk Valentina, Korzyukov Oleg, Tapaskar Natalie, Wagner Michael, Larson Charles R, Hammer Michael J
Department of Neurological Sciences, MEG laboratory, 12284UNMC, Omaha, NE, USA.
Wisconsin Airway Sensory Physiology Laboratory, 5229University of Wisconsin - Whitewater, Whitewater, WI, USA.
Clin EEG Neurosci. 2023 Mar;54(2):141-150. doi: 10.1177/15500594221115737. Epub 2022 Jul 21.
To characterize potential brain indexes of attention deficit hyperactivity disorder (ADHD) in adults. In an effort to develop objective, laboratory-based tests that can help to establish ADHD diagnosis, the brain indexes of distractibility was investigated in a group of adults. We used event-related brain potentials (ERPs) and performance measures in a forced-choice visual task. Behaviorally aberrant distractibility in the ADHD group was significantly higher. Across three ERP components of distraction: N1 enhancement, P300 (P3a), and Reorienting Negativity (RON) the significant difference between ADHD and matched controls was found in the amplitude of the RON. We used non-parametric randomization tests, enabling us to statistically validated this difference between-group. Our main results of this feasibility study suggest that among other ERP components associated with auditory distraction, the RON response is promising index for a potential biomarker of deficient re-orienting of attention in adults s with ADHD.
为了确定成人注意力缺陷多动障碍（ADHD）潜在的脑指标。为了开发有助于ADHD诊断的基于实验室的客观测试，我们对一组成年人的注意力分散脑指标进行了研究。我们在一项强制选择视觉任务中使用了事件相关脑电位（ERP）和行为表现测量方法。ADHD组中行为异常的注意力分散程度显著更高。在注意力分散的三个ERP成分中：N1增强、P300（P3a）和重新定向负波（RON），ADHD组与匹配对照组之间在RON波幅上存在显著差异。我们使用了非参数随机化检验，从而能够对组间差异进行统计学验证。这项可行性研究的主要结果表明，在与听觉注意力分散相关的其他ERP成分中，RON反应有望成为成人ADHD患者注意力重新定向不足潜在生物标志物的指标。
