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来自Quanta System的铥光纤激光器的初步临床经验:首批报告的50例病例。

Initial clinical experience with the thulium fiber laser from Quanta System: First 50 reported cases.

作者信息

Sierra Alba, Corrales Mariela, Kolvatzis Merkourios, Traxer Olivier

机构信息

Sorbonne University, GRC Urolithiasis No. 20 Tenon Hospital, 75020, Paris, France.

Department of Urology AP-HP, Sorbonne University, Tenon Hospital, 75020, Paris, France.

出版信息

World J Urol. 2022 Oct;40(10):2549-2553. doi: 10.1007/s00345-022-04096-y. Epub 2022 Jul 21.

Abstract

OBJECTIVE

To evaluate the new thulium fiber laser (TFL) from Quanta System (Fiber Dust™) in terms of efficiency, safety, and laser settings in laser lithotripsy during retrograde intrarenal surgery (RIRS).

METHODS

A prospective study of the first 50 patients with ureteral and renal stones who underwent RIRS using the new Fiber Dust (TFL from Quanta System, Italy) was performed in a single center. 200 µm and 150 µm laser fibers were used. Stone size, stone density, laser-on time (LOT) and laser settings were recorded. We also assessed the ablation speed (mm/s), Joules/mm and laser power (W) values for each procedure.

RESULTS

A total of 50 patients were analyzed. The median (IQR) age was 54.5 (43-65) years old. Median (IQR) stone volume was 347 (147-1800) mm and 1125 (294-4000) mm for ureteral and renal stones, respectively. Median (IQR) stone density was 900 (400-1500) HU for ureteral stones and 950 (725-1125) HU for renal stones. Median (IQR) pulse energy was 0.6 (0.5-1) J and 0.6 (0.5-0.9) J for ureteral and renal stones, respectively. Median (IQR) frequency for ureteral stones was 10 (10-20) Hz and for renal stones, 15 (10-20) Hz. All procedures used short pulse. There were no statistically significant differences in pulse energy, frequency, laser power or LOT in both groups. The median (IQR) J/mm was 8.7 (4.8-65.2) for ureteral stones vs 14.3 (7.8-24.7) for renal stones. The median (IQR) ablation rate was 0.3 (0.2-1.3) mm/s for ureteral stones vs 0.7 (0.4-1.2) mm/s for renal stones. Neither of those results reached the significance threshold. Overall complication rate was low in both groups, and none was related to TFL.

CONCLUSION

According to our results, the new TFL laser is safe and effective for lithotripsy during RIRS, using low pulse energy and low pulse frequency.

摘要

目的

在逆行性肾内手术(RIRS)的激光碎石术中,从效率、安全性和激光设置方面评估Quanta System公司的新型铥光纤激光器(TFL,Fiber Dust™)。

方法

在单一中心对首批50例使用新型Fiber Dust(意大利Quanta System公司的TFL)进行RIRS的输尿管和肾结石患者进行前瞻性研究。使用了200μm和150μm的激光光纤。记录结石大小、结石密度、激光开启时间(LOT)和激光设置。我们还评估了每个手术的消融速度(mm/s)、焦耳/毫米和激光功率(W)值。

结果

共分析了50例患者。年龄中位数(四分位间距)为54.5(43 - 65)岁。输尿管结石和肾结石的结石体积中位数(四分位间距)分别为347(147 - 1800)mm³和1125(294 - 4000)mm³。输尿管结石和肾结石的结石密度中位数(四分位间距)分别为900(400 - 1500)HU和950(725 - 1125)HU。输尿管结石和肾结石的脉冲能量中位数(四分位间距)分别为0.6(0.5 - 1)J和0.6(0.5 - 0.9)J。输尿管结石的频率中位数(四分位间距)为10(10 - 20)Hz,肾结石为15(10 - 20)Hz。所有手术均使用短脉冲。两组在脉冲能量、频率、激光功率或LOT方面均无统计学显著差异。输尿管结石的焦耳/毫米中位数(四分位间距)为8.7(4.8 - 65.2),肾结石为14.3(7.8 - 24.7)。输尿管结石的消融率中位数(四分位间距)为0.3(0.2 - 1.3)mm/s,肾结石为0.7(0.4 - 1.2)mm/s。这些结果均未达到显著性阈值。两组的总体并发症发生率均较低,且均与TFL无关。

结论

根据我们的结果,新型TFL激光在RIRS期间使用低脉冲能量和低脉冲频率进行碎石术是安全有效的。

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