Division of Pathology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, 1-15-1 Fukumuro, Miyagino-ku, Sendai, Miyagi, 983-8536, Japan.
Department of Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan.
Med Mol Morphol. 2022 Dec;55(4):283-291. doi: 10.1007/s00795-022-00332-x. Epub 2022 Jul 21.
Glucocorticoid receptor (GR) has been implicated in prostate carcinoma growth and progression. Glucocorticoid receptor beta (GRβ) acts as an inhibitor of GR; however, its function is not well understood. Serum- and glucocorticoid-regulated kinase 1 (SGK1) is a GR-responsive gene that phosphorylates N-myc downstream-regulated gene 1 (NDRG1) and is involved in cancer growth and invasion. However, the expression of GR, GRβ, SGK1, and NDRG1 in prostate cancer and their relationship with clinicopathological and functional significance remain unknown. The association between the status of GR, GRβ, SGK1, and NDRG1 immunoreactivity and clinicopathological variables was analyzed in patients with prostate carcinoma to explore their clinical significance. In prostate carcinoma cases, the relative abundance of GR and NDRG1 immunoreactivity was inversely and significantly associated with the primary tumor stage (pT), while GR immunoreactivity was inversely and significantly associated with the Ki-67 score. The relative expression status of NDRG1 was significantly associated with that of GR. However, no significant correlation was observed between any of the clinicopathological parameters and GRβ and SGK1 expression. Our findings indicate that GR and NDRG1 expression status is correlated with clinicopathological features in patients with prostate cancer.
糖皮质激素受体（GR）已被牵连到前列腺癌的生长和进展中。糖皮质激素受体β（GRβ）作为 GR 的抑制剂；然而，其功能尚不清楚。血清和糖皮质激素调节激酶 1（SGK1）是一种 GR 反应基因，可磷酸化 N-myc 下游调节基因 1（NDRG1），并参与癌症的生长和侵袭。然而，前列腺癌中 GR、GRβ、SGK1 和 NDRG1 的表达及其与临床病理和功能意义的关系尚不清楚。分析了前列腺癌患者中 GR、GRβ、SGK1 和 NDRG1 免疫反应的状态与临床病理变量之间的关系，以探讨其临床意义。在前列腺癌病例中，GR 和 NDRG1 免疫反应的相对丰度与原发性肿瘤分期（pT）呈负相关且显著相关，而 GR 免疫反应与 Ki-67 评分呈负相关且显著相关。NDRG1 的相对表达状态与 GR 显著相关。然而，任何临床病理参数与 GRβ 和 SGK1 表达之间均未观察到显著相关性。我们的研究结果表明，GR 和 NDRG1 的表达状态与前列腺癌患者的临床病理特征相关。
