用于阴离子传输和萃取的单功能化氟化竹节环脲及其共轭物
Monofunctionalized Fluorinated Bambusurils and Their Conjugates for Anion Transport and Extraction.
作者信息
De Simone Nicola Alessandro, Chvojka Matúš, Lapešová Jana, Martínez-Crespo Luis, Slávik Petr, Sokolov Jan, Butler Stephen J, Valkenier Hennie, Šindelář Vladimír
机构信息
Department of Chemistry, Faculty of Science, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.
RECETOX, Faculty of Science, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.
出版信息
J Org Chem. 2022 Aug 5;87(15):9829-9838. doi: 10.1021/acs.joc.2c00870. Epub 2022 Jul 21.
Bambusurils are macrocyclic molecules that are known for their high binding affinity and selectivity toward anions. Here, we present the preparation of two bambusurils bearing fluorinated substituents and one carboxylic function. These monofunctionalized bambusurils were conjugated with crown ether and cholesterol units. The resulting conjugates were successfully tested in liquid-liquid extraction of inorganic salts and chloride/bicarbonate transport across lipid bilayers.
竹节环肽是一类大环分子，以其对阴离子具有高结合亲和力和选择性而闻名。在此，我们展示了两种带有氟取代基和一个羧基官能团的竹节环肽的制备方法。这些单官能化的竹节环肽与冠醚和胆固醇单元共轭。所得共轭物成功用于无机盐的液 - 液萃取以及氯离子/碳酸氢根离子跨脂质双层的转运测试。
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