海马 KCNQ2 通道在氯胺酮抗抑郁作用中的作用。
The role of hippocampal KCNQ2 channel in antidepressant actions of ketamine.
机构信息
Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba 260-8670, Japan; Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China.
Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba 260-8670, Japan.
出版信息
Neuron. 2022 Jul 20;110(14):2201-2203. doi: 10.1016/j.neuron.2022.05.027.
In this issue of Neuron, Lopez et al. report that KCNQ2 (potassium voltage-gated channel subfamily Q member 2) is essential for the sustained antidepressant-like effects of ketamine in glutamatergic neurons of the ventral hippocampus. This study implies that KCNQ2 activators can be novel antidepressants without the ketamine side effects.
在本期《神经元》杂志中，Lopez 等人报告称，KCNQ2（钾电压门控通道亚家族 Q 成员 2）对于氯胺酮在腹侧海马体谷氨酸能神经元中产生持续的抗抑郁样作用是必不可少的。这项研究表明，KCNQ2 激活剂可以成为没有氯胺酮副作用的新型抗抑郁药。
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