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Comments to behavioral tests for antidepressant-like actions of (2R,6R)-hydroxynorketamine by Bonaventura et al.

作者信息

Chang Lijia, Hashimoto Kenji

机构信息

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan.

出版信息

Mol Psychiatry. 2024 Jan;29(1):3-4. doi: 10.1038/s41380-022-01766-6. Epub 2022 Sep 13.

DOI:10.1038/s41380-022-01766-6
PMID:36100667
Abstract
摘要

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()-hydroxynorketamine exerts mGlu receptor-dependent antidepressant actions.()-羟基去甲氯胺通过 mGlu 受体发挥抗抑郁作用。
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Lack of Antidepressant Effects of (2R,6R)-Hydroxynorketamine in a Rat Learned Helplessness Model: Comparison with (R)-Ketamine.（2R,6R）-羟基去甲氯胺酮在大鼠习得性无助模型中缺乏抗抑郁作用：与（R）-氯胺酮的比较。
Int J Neuropsychopharmacol. 2018 Jan 1;21(1):84-88. doi: 10.1093/ijnp/pyx108.
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Brain-derived neurotrophic factor in the ventrolateral periaqueductal gray contributes to (2R,6R)-hydroxynorketamine-mediated actions.脑源性神经营养因子在腹外侧导水管周围灰质中有助于（2R,6R）-羟基去甲氯胺酮介导的作用。
Neuropharmacology. 2020 Jun 15;170:108068. doi: 10.1016/j.neuropharm.2020.108068. Epub 2020 Mar 25.
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Activity-dependent brain-derived neurotrophic factor signaling is required for the antidepressant actions of (2,6)-hydroxynorketamine.（2,6）-羟基去甲氯胺的抗抑郁作用需要依赖活性的脑源性神经营养因子信号传导。
Proc Natl Acad Sci U S A. 2019 Jan 2;116(1):297-302. doi: 10.1073/pnas.1814709116. Epub 2018 Dec 17.
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Antidepressant-relevant concentrations of the ketamine metabolite (2,6)-hydroxynorketamine do not block NMDA receptor function.抗抑郁相关浓度的氯胺酮代谢产物 (2,6)-羟基去甲氯胺酮不会阻断 NMDA 受体功能。
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(R)-Ketamine exerts antidepressant actions partly via conversion to (2R,6R)-hydroxynorketamine, while causing adverse effects at sub-anaesthetic doses.(R)-氯胺酮通过转化为（2R,6R）-羟基去甲氯胺酮发挥抗抑郁作用，而在亚麻醉剂量下会引起不良反应。
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(2R,6R)-hydroxynorketamine rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray.（2R，6R）-羟基去甲氯胺通过作用于中脑导水管周围灰质来挽救慢性应激诱导的抑郁样行为。
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Bibliometric insights into astrocytic roles in depression and treatment.关于星形胶质细胞在抑郁症及治疗中作用的文献计量学见解
Front Cell Neurosci. 2025 Jan 15;18:1521398. doi: 10.3389/fncel.2024.1521398. eCollection 2024.
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Are "mystical experiences" essential for antidepressant actions of ketamine and the classic psychedelics?“神秘体验”对于氯胺酮和经典致幻剂的抗抑郁作用是否至关重要？
Eur Arch Psychiatry Clin Neurosci. 2024 Feb 27. doi: 10.1007/s00406-024-01770-7.
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Arketamine for cognitive impairment in psychiatric disorders.氯胺酮治疗精神障碍的认知障碍。

本文引用的文献

1
The role of hippocampal KCNQ2 channel in antidepressant actions of ketamine.海马 KCNQ2 通道在氯胺酮抗抑郁作用中的作用。
Neuron. 2022 Jul 20;110(14):2201-2203. doi: 10.1016/j.neuron.2022.05.027.
2
A systematic review of studies investigating the acute effects of -methyl--aspartate receptor antagonists on behavioural despair in normal animals suggests poor predictive validity.一项对研究 N-甲基-D-天冬氨酸受体拮抗剂对正常动物行为绝望急性影响的研究的系统评价表明，预测效度不佳。
Brain Neurosci Adv. 2022 Mar 12;6:23982128221081645. doi: 10.1177/23982128221081645. eCollection 2022 Jan-Dec.
3
Molecular mechanisms underlying the antidepressant actions of arketamine: beyond the NMDA receptor.
Eur Arch Psychiatry Clin Neurosci. 2023 Oct;273(7):1513-1525. doi: 10.1007/s00406-023-01570-5. Epub 2023 Feb 14.
4
A Bibliometric Analysis of Research on the Role of BDNF in Depression and Treatment.BDNF 在抑郁症及其治疗中的作用的文献计量学分析
Biomolecules. 2022 Oct 12;12(10):1464. doi: 10.3390/biom12101464.
亚胺培南抗抑郁作用的分子机制：超越 NMDA 受体。
Mol Psychiatry. 2022 Jan;27(1):559-573. doi: 10.1038/s41380-021-01121-1. Epub 2021 May 7.
4
Pharmacological and behavioral divergence of ketamine enantiomers: implications for abuse liability.氯胺酮对映异构体的药理学和行为学差异：对滥用倾向的影响。
Mol Psychiatry. 2021 Nov;26(11):6704-6722. doi: 10.1038/s41380-021-01093-2. Epub 2021 Apr 15.
5
Ketamine metabolites, clinical response, and gamma power in a randomized, placebo-controlled, crossover trial for treatment-resistant major depression.在一项针对难治性重度抑郁症的随机、安慰剂对照、交叉试验中，氯胺酮代谢物、临床反应和γ波功率
Neuropsychopharmacology. 2020 Jul;45(8):1398-1404. doi: 10.1038/s41386-020-0663-6. Epub 2020 Apr 6.
6
Molecular mechanisms of the rapid-acting and long-lasting antidepressant actions of (R)-ketamine.（R）-氯胺酮快速抗抑郁作用和长效作用的分子机制。
Biochem Pharmacol. 2020 Jul;177:113935. doi: 10.1016/j.bcp.2020.113935. Epub 2020 Mar 26.
7
Intravenous arketamine for treatment-resistant depression: open-label pilot study.静脉注射氯胺酮治疗难治性抑郁症：开放标签试点研究。
Eur Arch Psychiatry Clin Neurosci. 2021 Apr;271(3):577-582. doi: 10.1007/s00406-020-01110-5. Epub 2020 Feb 20.
8
Depression researchers rethink popular mouse swim tests.抑郁症研究人员重新思考常用的小鼠游泳测试。
Nature. 2019 Jul;571(7766):456-457. doi: 10.1038/d41586-019-02133-2.
9
(2R,6R)-Hydroxynorketamine is not essential for the antidepressant actions of (R)-ketamine in mice.（2R,6R）-羟基去甲氯胺对于（R）-氯胺酮在小鼠中的抗抑郁作用并非必需。
Neuropsychopharmacology. 2018 Aug;43(9):1900-1907. doi: 10.1038/s41386-018-0084-y. Epub 2018 May 3.
10
Ketamine has distinct electrophysiological and behavioral effects in depressed and healthy subjects.氯胺酮对抑郁和健康受试者具有明显的电生理和行为效应。
Mol Psychiatry. 2019 Jul;24(7):1040-1052. doi: 10.1038/s41380-018-0028-2. Epub 2018 Feb 27.