Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Biomolecules. 2022 Oct 12;12(10):1464. doi: 10.3390/biom12101464.
Brain-derived neurotrophic factor (BDNF), as the most widely distributed and widely studied neurotrophic factor in the mammalian brain, plays a key role in depression and the mechanisms of action for antidepressants. Currently, there is a large number of studies on the role of BDNF in the pathogenesis and therapeutic mechanism of depression. The quantity and quality of these studies, however, are unknown. To give beginners a quicker introduction to this research topic, we therefore performed a bibliometric analysis. A total of 5300 publications were included. We obtained the publications on this topic from the Web of Science database, and a variety of bibliographic elements were collected, including annual publications, authors, countries/regions, institutions, journals, and keywords. Moreover, we found that oxidative stress and neuroinflammation are the hotspots in the field in very recent years. Collectively, this study provides a comprehensive summary and analysis on the role of BDNF in depression and its treatment and offers meaningful values for beginners on this topic.
脑源性神经营养因子（BDNF）作为哺乳动物大脑中分布最广泛、研究最广泛的神经营养因子，在抑郁症及其抗抑郁药作用机制中起着关键作用。目前，已有大量关于 BDNF 在抑郁症发病机制和治疗机制中的作用的研究。然而，这些研究的数量和质量尚不清楚。为了让初学者更快地了解这个研究课题，我们进行了文献计量学分析。共纳入 5300 篇文献。我们从 Web of Science 数据库中获取了关于这个主题的出版物，并收集了各种书目元素，包括年度出版物、作者、国家/地区、机构、期刊和关键词。此外，我们发现氧化应激和神经炎症是近年来该领域的热点。总的来说，本研究对 BDNF 在抑郁症及其治疗中的作用进行了全面的总结和分析，为该领域的初学者提供了有意义的价值。
