Suzuki T, Shirai M, Endo S, Somiya Y, Sakai A, Nakanishi D, Morishita M
Jpn J Antibiot. 1987 Jan;40(1):232-7.
Plasma concentrations after a single or multiple intramuscular administrations of isepamicin sulfate (HAPA-B) at dose levels of 6.25, 25 and 100 mg/kg to male and female dogs were measured by microbiological assay, and were also compared with those of amikacin at dose levels of 25 and 100 mg/kg. Shapes of plasma concentration curves after multiple administrations of HAPA-B were very similar to those after single administrations at all dosage levels tested. On the other hand, the shape of plasma concentration curve after multiple administration of amikacin at 100 mg/kg was markedly different from that after a single administration.
通过微生物学测定法，测量了硫酸异帕米星（HAPA - B）以6.25、25和100mg/kg剂量水平对雄性和雌性犬单次或多次肌肉注射后的血浆浓度，并且还将其与25和100mg/kg剂量水平的阿米卡星的血浆浓度进行了比较。在所有测试剂量水平下，多次注射HAPA - B后的血浆浓度曲线形状与单次注射后的非常相似。另一方面，100mg/kg剂量多次注射阿米卡星后的血浆浓度曲线形状与单次注射后的明显不同。
