Dutta Bhaskar Jyoti, Singh Shamsher, Seksaria Sanket, Das Gupta Ghanshyam, Singh Amrita
Department of Pharmacology, ISF College of Pharmacy, GT Road, Ghal Kalan, Moga 142001, Punjab, India.
Department of Pharmacology, ISF College of Pharmacy, GT Road, Ghal Kalan, Moga 142001, Punjab, India.
Pharmacol Res. 2022 Aug;182:106358. doi: 10.1016/j.phrs.2022.106358. Epub 2022 Jul 18.
Type 2 diabetes mellitus (T2DM) the most prevalent metabolic disease that has evolved into a major public health issue. Concerning about its secondary complications, a growing body of evidence links T2DM to cognitive impairment and neurodegenerative disorders. The underlying pathology behind this secondary complication disease is yet to be fully known. Nonetheless, they are likely to be associated with poor insulin signaling as a result of insulin resistance. We have combed through a rising body of literature on insulin signaling in the normal and diabetic brains along with various factors like insulin resistance, hyperglycemia, obesity, oxidative stress, neuroinflammation and Aβ plaques which can act independently or synergistically to link T2DM with cognitive impairments. Finally, we explored several pharmacological and non-pharmacological methods in the hopes of accelerating the rational development of medications for cognitive impairment in T2DM by better understanding these shared pathways.
2型糖尿病（T2DM）是最普遍的代谢性疾病，已演变成一个重大的公共卫生问题。关于其继发性并发症，越来越多的证据将T2DM与认知障碍和神经退行性疾病联系起来。这种继发性并发症疾病背后的潜在病理尚未完全明确。尽管如此，它们可能与胰岛素抵抗导致的胰岛素信号传导不良有关。我们梳理了大量关于正常和糖尿病大脑中胰岛素信号传导的文献，以及胰岛素抵抗、高血糖、肥胖、氧化应激、神经炎症和Aβ斑块等各种因素，这些因素可单独或协同作用，将T2DM与认知障碍联系起来。最后，我们探索了几种药理学和非药理学方法，希望通过更好地理解这些共同途径，加速T2DM认知障碍药物的合理开发。
