Universidade Federal De Pernambuco -, Departamento de Bioquímica, Recife PE, 50670-901, Brazil.
Universidade Federal De Pernambuco -, Departamento de Química Fundamental, Recife PE, 50670-901, Brazil.
Chem Biodivers. 2022 Sep;19(9):e202200034. doi: 10.1002/cbdv.202200034. Epub 2022 Aug 11.
The purpose of this study was to analyses the influence of seasonal variation on the chemical composition and antimicrobial, antioxidant and cytotoxicity activities of the essential oil (EO) extracted from the leaves of Eugenia pohliana. Chemical characterization of the samples - by gas chromatography-mass spectrometry - found 35 and 38 components for summer and winter, respectively, of the EO from E. pohliana leaves, totaling 47 different compounds. Analysis of antioxidant capacity (DPPH, ABTS and TAC) revealed that the summer EO showed greater free radical scavenging capacity than the winter. Similarly, the summer EO exhibited superior antimicrobial potential (MIC=128-512 μg/mL and MMC=128-1024 μg/mL, compared to the winter EO (128-2048 μg/mL and 256-2048 μg/mL, respectively). Results showed that both oils had a low potential to cause hemolysis. This study provides new scientific evidence on the influence of seasonality on the pharmacological properties of E. pohliana leaves and its potential for the development of herbal medicines.
本研究旨在分析季节变化对采自桃金娘科植物丁香树叶的精油（EO）的化学成分、抗菌、抗氧化和细胞毒性活性的影响。通过气相色谱-质谱联用分析对样品进行化学特征分析，发现夏季和冬季的 EO 分别有 35 种和 38 种成分，总计有 47 种不同的化合物。抗氧化能力（DPPH、ABTS 和 TAC）分析表明，夏季 EO 的自由基清除能力大于冬季 EO。同样，夏季 EO 表现出更强的抗菌潜力（MIC=128-512 μg/mL 和 MMC=128-1024 μg/mL，而冬季 EO 分别为 128-2048 μg/mL 和 256-2048 μg/mL）。结果表明，两种精油的溶血潜力均较低。本研究为季节变化对丁香树叶的药理学特性及其在草药开发中的潜在应用提供了新的科学证据。
