Mailankody Pooja, Battu Rajani, Lenka Abhishek, Mohammed Shereef P M, Thennarasu K, Yadav Ravi, Pal Pramod Kumar
Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, Karnataka, India.
Medical Director, Centre for Eye Genetics and Research, Bangalore, Karnataka, India.
Neurol India. 2022 May-Jun;70(3):1149-1153. doi: 10.4103/0028-3886.349658.
There is definite evidence for the involvement of retina in Parkinson's disease (PD). However, a specific pattern has not been clear due to the cross-sectional nature of the majority of the previous studies.
The aim of this work was to study the pattern of changes in the retinal layers in patients with PD on longitudinal follow-up.
Twelve patients with PD (23 eyes) were evaluated at baseline with complete history, clinical examination, Unified Parkinson's Disease Rating Scale (UPDRS) motor part, visual acuity, and retinal imaging with spectral-domain Optical Coherence Tomography. After a mean duration of 3.7 ± 0.46 years, patients were re-evaluated.
The Central Macular Thickness (CMT) of the right eye was found to be significantly thicker during the follow-up (P = 0.002). The outer retinal layer in the temporal quadrant at 0.5 centimeters from the fovea of the left eye was found to be significantly thinner (P = 0.001).
The serial evaluation of the retinal layers in patients with PD suggests a progressive loss of thickness of the outer retinal layer. The involvement of non-dopaminergic mechanisms, especially glutamatergic pathways, may be responsible for these changes.
有确切证据表明视网膜参与帕金森病（PD）。然而，由于大多数先前研究的横断面性质，具体模式尚不清楚。
本研究旨在对PD患者进行纵向随访，以研究视网膜各层的变化模式。
对12例PD患者（23只眼）进行基线评估，包括完整病史、临床检查、统一帕金森病评定量表（UPDRS）运动部分、视力以及使用光谱域光学相干断层扫描进行视网膜成像。平均随访3.7±0.46年后，对患者进行重新评估。
随访期间发现右眼中央黄斑厚度（CMT）显著增厚（P = 0.002）。发现左眼距黄斑中心凹0.5厘米处颞侧象限的视网膜外层显著变薄（P = 0.001）。
对PD患者视网膜各层的系列评估表明视网膜外层厚度逐渐丧失。非多巴胺能机制，尤其是谷氨酸能通路的参与，可能是这些变化的原因。
