Altintaş Ozgül, Işeri Pervin, Ozkan Berna, Cağlar Yusuf
Department of Ophthalmology, Kocaeli University Medical School, Kocaeli, Turkey.
Doc Ophthalmol. 2008 Mar;116(2):137-46. doi: 10.1007/s10633-007-9091-8. Epub 2007 Oct 26.
To measure the parapapillary retinal nerve fiber layer and macular thickness and macular volume in vivo and to evaluate whether retinal structural changes and visual cortical responses may be related to the clinical severity of the PD.
We included 17 patients with Parkinson's disease and 11 healthy subjects of a similar age. Unified Parkinson's disease rating scale scores in Parkinson's disease and control subjects were assessed for clinical evaluation. The retinal nerve fiber layer thickness, macular thickness and volume were measured by commercially available optical coherence tomography Model 3000 unit. Peak latencies of P100 component were measured by pattern visual evoked potential examination.
The mean retinal nerve fiber layer average thickness was significantly reduced in Parkinson's disease patients (98.76 +/- 10.90 microm) when compared with those of control subjects (114.54 +/- 5.72) (P < 0.05). The retinal thickness reduction was statistically significant in superior inner macula; temporal, nasal and inferior quadrants of outer macula (P < 0.05)(Table 2). The mean total macular volume of Parkinson's disease patients (6.82 +/- 0.32 mm(3)) was significantly reduced when compared with those of control subjects (7.09 +/- 0.23 mm(3)). Highly significant inverse correlation between foveal retinal thickness and total and motor subscores of Unified Parkinson's disease rating scale was observed in Parkinson's disease patients, respectively (r = -0.660; P = 0.004), (r = -0.625, P = 0.007). There was a moderate nearly significant inverse correlation between total macular volume and P100 latency in PD (r = -0.328; P = 0.058).
In Parkinson's disease patients there is a reduction of retinal nerve fiber layer thickness, macular thickness and volume evaluated in vivo by optical coherence tomography. Reduced foveal thickness which is not found to be statistically different from normal is correlated to the severity of disease.
在活体状态下测量视乳头旁视网膜神经纤维层、黄斑厚度及黄斑容积，并评估视网膜结构变化和视皮质反应是否可能与帕金森病（PD）的临床严重程度相关。
我们纳入了17例帕金森病患者和11名年龄相仿的健康受试者。对帕金森病患者和对照受试者进行统一帕金森病评定量表评分以进行临床评估。使用市售的3000型光学相干断层扫描仪测量视网膜神经纤维层厚度、黄斑厚度及容积。通过图形视觉诱发电位检查测量P100成分的峰潜伏期。
与对照受试者（114.54±5.72）相比，帕金森病患者的视网膜神经纤维层平均厚度显著降低（98.76±10.90μm）（P<0.05）。黄斑上内侧、黄斑外侧颞侧、鼻侧及下象限的视网膜厚度降低具有统计学意义（P<0.05）（表2）。与对照受试者（7.09±0.23mm³）相比，帕金森病患者的黄斑平均总体积（6.82±0.32mm³）显著降低。在帕金森病患者中，分别观察到中央凹视网膜厚度与统一帕金森病评定量表的总分及运动分项评分之间存在高度显著的负相关（r=-0.660；P=0.004），（r=-0.625，P=0.007）。在PD患者中，黄斑总体积与P100潜伏期之间存在中度且接近显著的负相关（r=-0.328；P=0.058）。
通过光学相干断层扫描在活体状态下评估发现，帕金森病患者的视网膜神经纤维层厚度、黄斑厚度及容积降低。中央凹厚度降低与疾病严重程度相关，虽未发现其与正常情况存在统计学差异。
