3rd Department of Cardiology, Sotiria Thoracic Diseases General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Department of Clinical Therapeutics, Alexandra Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Curr Pharm Des. 2022;28(26):2129-2130. doi: 10.2174/1381612828666220720095433.
Coronary artery disease, autonomic neuropathy, and diabetic cardiomyopathy are the most common cardiovascular complications of diabetes. However, emerging evidence demonstrates that diabetes also affects the heart's electrical conduction system, culminating in lethal arrhythmias and sudden cardiac death. Diabetes and rhythm disturbances have a complex relationship, and arrhythmias cannot only be attributed to ischemia and autonomic neuropathy. Hypoglycemia, hyperglycemia, and glucose fluctuations can potentially induce arrhythmias by activating various pathways. Structural remodeling can accelerate and exacerbate disease development. Mitochondrial dysfunction can also alter the structure and metabolism of cardiomyocytes and contribute to disease progression through oxidative stress and inflammation.
冠心病、自主神经病变和糖尿病性心肌病是糖尿病最常见的心血管并发症。然而，新出现的证据表明，糖尿病还会影响心脏的电传导系统，最终导致致命性心律失常和心源性猝死。糖尿病与节律紊乱之间存在复杂的关系，心律失常不仅归因于缺血和自主神经病变。低血糖、高血糖和血糖波动可能通过激活各种途径引发心律失常。结构重塑可以加速和加剧疾病的发展。线粒体功能障碍也可以改变心肌细胞的结构和代谢，并通过氧化应激和炎症促进疾病的进展。
