Kambale-Kombi Paul, Djang'eing'a Roland Marini, Alworong'a Opara Jean-Pierre, Mbo Mukonkole Jean-Paulin, Bours Vincent, Tonen-Wolyec Serge, Mbumba Lupaka Dieu-Merci, Bome Lucien Bolukaoto, Tshilumba Charles Kayembe, Batina-Agasa Salomon
Department of Internal Medicine, Faculty of Medicine and Pharmacy, University of Kisangani, Kisangani, Democratic Republic of the Congo.
Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Kisangani, Kisangani, Democratic Republic of the Congo.
Mediterr J Hematol Infect Dis. 2022 Jul 1;14(1):e2022046. doi: 10.4084/MJHID.2022.046. eCollection 2022.
Sickle cell disease (SCD) is now a well-established cause of renal damage. In the northeast of the Democratic Republic of Congo (DRC), SCD is common. However, sickle cell nephropathy remains unstudied in this region. Thus, this study aimed to assess renal abnormalities in SCD patients in Kisangani (northeastern DRC).
This cross-sectional study included 98 sickle cell patients selected from six health facilities in Kisangani and 89 healthy non-sickle cell subjects as the control group. Based on a survey form, a clinical examination and biological tests were performed to collect data related to the sex, age, weight, height, pressure, serum creatinine, serum uric acid, urinary albumin/creatinine ratio, and hemoglobin phenotype. We used a spectrophotometer to measure serum creatinine and uricemia, the sickle SCAN® device for hemoglobin phenotype, and an automatic multifunction analyzer for urine albumin/creatinine ratio. Data were entered into an Excel file and analyzed on SPSS 20.0.
The mean urine albumin-to-creatinine ratio was 11.79±9.03 mg/mmol in SCD patients, significantly higher than in AA (1.69±1.89 mg/mmol) and AS (2.97±4.46 mg/mmol) subjects. The decrease in glomerular filtration rate was more observed in SCD patients with hyperuricemia compared to those with normal uric acid levels. A significantly elevated prevalence of chronic kidney disease was observed among SCD patients (87.8%) compared to 23.8% in AS and 7.7% in AA subjects.
This study highlighted that albuminuria and chronic kidney disease are common in SCD patients in Kisangani. More studies are needed to further document these complications.
镰状细胞病（SCD）现已被确认为肾脏损伤的一个既定病因。在刚果民主共和国（DRC）东北部，SCD很常见。然而，该地区的镰状细胞肾病仍未得到研究。因此，本研究旨在评估基桑加尼（刚果民主共和国东北部）SCD患者的肾脏异常情况。
这项横断面研究纳入了从基桑加尼的六个医疗机构选取的98例镰状细胞病患者以及89例健康的非镰状细胞病患者作为对照组。根据一份调查问卷，进行了临床检查和生物学检测，以收集与性别、年龄、体重、身高、血压、血清肌酐、血清尿酸、尿白蛋白/肌酐比值和血红蛋白表型相关的数据。我们使用分光光度计测量血清肌酐和血尿酸，使用镰状SCAN®设备检测血红蛋白表型，并使用自动多功能分析仪检测尿白蛋白/肌酐比值。数据录入Excel文件，并在SPSS 20.0上进行分析。
SCD患者的平均尿白蛋白与肌酐比值为11.79±9.03mg/mmol，显著高于AA型（1.69±1.89mg/mmol）和AS型（2.97±4.46mg/mmol）受试者。与尿酸水平正常的SCD患者相比，高尿酸血症的SCD患者肾小球滤过率下降更为明显。与AS型受试者中的23.8%和AA型受试者中的7.7%相比，SCD患者中慢性肾脏病的患病率显著升高（87.8%）。
本研究强调了蛋白尿和慢性肾脏病在基桑加尼的SCD患者中很常见。需要更多研究来进一步记录这些并发症。
