Asadi Mohammad Reza, Moslehian Marziyeh Sadat, Sabaie Hani, Sharifi-Bonab Mirmohsen, Hakimi Parvin, Hussen Bashdar Mahmud, Taheri Mohammad, Rakhshan Azadeh, Rezazadeh Maryam
Clinical Research Development Unit of Tabriz Valiasr Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
Woman's Reproductive Health Research Center, Tabriz University of medical sciences, Tabriz, Iran.
Front Oncol. 2022 Jul 5;12:910470. doi: 10.3389/fonc.2022.910470. eCollection 2022.
Retinoblastoma (RB) is one of the most common childhood cancers caused by RB gene mutations (tumor suppressor gene in various patients). A better understanding of molecular pathways and the development of new diagnostic approaches may lead to better treatment for RB patients. The number of studies on ceRNA axes is increasing, emphasizing the significance of these axes in RB. Circular RNAs (circRNAs) play a vital role in competing endogenous RNA (ceRNA) regulatory axes by sponging microRNAs and regulating gene expression. Because of the broadness of ceRNA interaction networks, they may assist in investigating treatment targets in RB. This study conducted a systematic scoping review to evaluate verified loops of ceRNA in RB, focusing on the ceRNA axis and its relationship to circRNAs. This scoping review was carried out using a six-step strategy and the Prisma guideline, and it involved systematically searching the publications of seven databases. Out of 363 records, sixteen articles were entirely consistent with the defined inclusion criteria and were summarized in the relevant table. The majority of the studies focused on the circRNAs circ_0000527, circ_0000034, and circTET1, with approximately two-fifths of the studies focusing on a single circRNA. Understanding the many features of this regulatory structure may help elucidate RB's unknown causative factors and provide novel molecular potential therapeutic targets and medical fields.
视网膜母细胞瘤（RB）是由RB基因突变（不同患者中的肿瘤抑制基因）引起的最常见的儿童癌症之一。更好地理解分子途径和开发新的诊断方法可能会为RB患者带来更好的治疗效果。关于ceRNA轴的研究数量在不断增加，这凸显了这些轴在RB中的重要性。环状RNA（circRNA）通过吸附微小RNA并调节基因表达，在竞争性内源性RNA（ceRNA）调控轴中发挥着至关重要的作用。由于ceRNA相互作用网络的广泛性，它们可能有助于研究RB中的治疗靶点。本研究进行了一项系统的范围综述，以评估RB中已证实的ceRNA环，重点关注ceRNA轴及其与circRNA的关系。该范围综述采用六步策略和Prisma指南进行，涉及系统检索七个数据库的出版物。在363条记录中，有16篇文章完全符合定义的纳入标准，并在相关表格中进行了总结。大多数研究集中在circRNAs circ_0000527、circ_0000034和circTET1上，约五分之二的研究集中在单个circRNA上。了解这种调控结构的多种特征可能有助于阐明RB未知的致病因素，并提供新的分子潜在治疗靶点和医学领域。
