Key Laboratory of Neuroregeneration, Ministry of Education and Jiangsu Province, Co-Innovation Center of Neuroregeneration, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Nantong University, Nantong, China.
Medical School of Nantong University, Nantong University, Nantong, China.
Front Immunol. 2022 Jul 5;13:923152. doi: 10.3389/fimmu.2022.923152. eCollection 2022.
The immune system is essential in the process of nerve repair after injury. Successful modulation of the immune response is regarded as an effective approach to improving treatment outcomes. T cells play an important role in the immune response of the nervous system, and their beneficial roles in promoting regeneration have been increasingly recognized. However, the diversity of T-cell subsets also delivers both neuroprotective and neurodegenerative functions. Therefore, this review mainly discusses the beneficial impact of T-cell subsets in the repair of both peripheral nervous system and central nervous system injuries and introduces studies on various therapies based on T-cell regulation. Further discoveries in T-cell mechanisms and multifunctional biomaterials will provide novel strategies for nerve regeneration.
免疫系统在神经损伤后的修复过程中至关重要。成功调节免疫反应被认为是改善治疗效果的有效方法。T 细胞在神经系统的免疫反应中发挥着重要作用,它们在促进再生方面的有益作用已逐渐得到认可。然而,T 细胞亚群的多样性也具有神经保护和神经退行性的双重功能。因此,本综述主要讨论 T 细胞亚群在修复周围神经系统和中枢神经系统损伤中的有益影响,并介绍基于 T 细胞调节的各种治疗方法的研究。进一步发现 T 细胞的机制和多功能生物材料将为神经再生提供新的策略。