Department of Clinical and Biological Sciences, University of Torino, 10043 Orbassano, (Torino), Italy.
Neuroscience Institute Cavalieri Ottolenghi (NICO), 10043 Orbassano, (Torino), Italy.
Int J Mol Sci. 2022 May 5;23(9):5177. doi: 10.3390/ijms23095177.
Peripheral nerves are frequently affected by lesions caused by trauma (work accidents, car incidents, combat injuries) and following surgical procedures (for instance cancer resection), resulting in loss of motor and sensory function with lifelong impairments. Irrespective of the intrinsic capability of the peripheral nervous system for regeneration, spontaneous or surgically supported regeneration is often unsatisfactory with the limited functional success of nerve repair. For this reason, many efforts have been made to improve the regeneration process. Beyond innovative microsurgical methods that, in certain cases, are necessary to repair nerve injuries, different nonsurgical treatment approaches and adjunctive therapies have been investigated to enhance nerve regeneration. One possibility could be taking advantage of a healthy diet or lifestyle and their relation with proper body functions. Over the years, scientific evidence has been obtained on the benefits of the intake of polyphenols or polyphenol-rich foods in humans, highlighting the neuroprotective effects of these compounds in many neurodegenerative diseases. In order to improve the available knowledge about the potential beneficial role of polyphenols in the process of peripheral nerve regeneration, this review assessed the biological effects of polyphenol administration in supporting and promoting the regenerative process after peripheral nerve injury.
周围神经经常受到创伤（工作事故、车祸、战斗伤害）和手术（例如癌症切除）引起的病变的影响，导致运动和感觉功能丧失，终身受损。无论周围神经系统的内在再生能力如何，自发或手术支持的再生通常都不能令人满意，神经修复的功能效果有限。出于这个原因，人们做出了许多努力来改善再生过程。除了在某些情况下必须修复神经损伤的创新显微外科方法外，还研究了不同的非手术治疗方法和辅助治疗方法，以增强神经再生。一种可能性是利用健康的饮食或生活方式及其与适当身体功能的关系。多年来，人类摄入多酚或富含多酚的食物的益处已经得到了科学证据的支持，突出了这些化合物在许多神经退行性疾病中的神经保护作用。为了提高对多酚在周围神经再生过程中潜在有益作用的现有认识，本综述评估了多酚给药在支持和促进周围神经损伤后再生过程中的生物学作用。
