Zhang Qiaoli, Yang Yang, Xia Junmei, Zhang Yingying, Liu Shilei, Yuan Zhiqin
State Key Laboratory of NBC Protection for Civilian Beijing 102205 China
State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology Beijing 100029 China
RSC Adv. 2022 Jul 1;12(30):19246-19252. doi: 10.1039/d2ra02420a. eCollection 2022 Jun 29.
It has been a challenge to achieve rapid, simple, and effective discrimination of organophosphorus nerve agents (typical chemical warfare agents) due to the similar chemical properties of the targets such as sarin, soman, cyclosarin and VX. In this study, we propose a chemiluminescence sensor array that can effectively discriminate organophosphorus nerve agents by organophosphorus-HO reaction, which produces peroxyphosphonate intermediate and regulates the chemiluminescence intensity. A simple chemiluminescence sensor array based on different chemiluminescence characteristics of the four organophosphorus nerve agents in the luminol-HO system and layered double hydroxide-luminol-HO system has been constructed. Four agents can be well distinguished at a concentration of 1.0 mg L when linear discriminant analyses and hierarchical cluster analyses are smartly combined. The high accuracy (100%) evaluation of 20 blind samples demonstrates the practicability of this proposed chemiluminescence sensor array.
由于沙林、梭曼、环沙林和VX等目标物具有相似的化学性质，实现对有机磷神经毒剂（典型的化学战剂）快速、简单且有效的鉴别一直是一项挑战。在本研究中，我们提出了一种化学发光传感器阵列，其可通过有机磷-HO反应有效鉴别有机磷神经毒剂，该反应会产生过氧膦酸酯中间体并调节化学发光强度。基于鲁米诺-HO体系和层状双氢氧化物-鲁米诺-HO体系中四种有机磷神经毒剂不同的化学发光特性，构建了一种简单的化学发光传感器阵列。当将线性判别分析和层次聚类分析巧妙结合时，在浓度为1.0 mg/L时可很好地区分这四种毒剂。对20个盲样的高精度（100%）评估证明了所提出的这种化学发光传感器阵列的实用性。
