[补体系统第8成分家族性缺陷中的复发性脑膜炎]
[Recurrent meningitis in familial deficiency of the 8th component of the complement system].
作者信息
Keller H, Löke S, Hänsch G M, Jentschura D, Gerhard H, Heene D L
出版信息
Klin Wochenschr. 1987 Apr 15;65(8):387-90. doi: 10.1007/BF01745581.
PMID:3586574
Abstract
An 18-year-old man suffered from recurrent bacterial meningitis. Investigation of the complement system revealed deficiency of the 8th complement component (C8) in the patient and his sister. Genetic defects of the terminal complement components C5 to C8 predispose to Neisseria infections, probably due to a lack in bacteriolytic activity. It is to be noted that 1 year ago the patient had been hospitalized for a culture-proved pneumococcal meningitis.
摘要
一名18岁男性患有复发性细菌性脑膜炎。对补体系统的检查发现该患者及其妹妹缺乏第八补体成分（C8）。终末补体成分C5至C8的基因缺陷易导致奈瑟菌感染，可能是由于缺乏溶菌活性。需要注意的是，1年前该患者曾因培养证实的肺炎球菌性脑膜炎住院治疗。
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