一例转移性甲状腺内胸腺癌的基因组和免疫微环境分析
Genomic and immune microenvironment profiling in a case of metastatic intrathyroid thymic carcinoma.
作者信息
Ishii Hiroki, Tsujikawa Takahiro, Oishi Naoki, Kinouchi Arisa, Sakamoto Kaname, Mitsuda Junichi, Ogi Hiroshi, Itoh Kyoko, Kondo Tetsuo, Hirano Shigeru, Sakurai Daiju
机构信息
Department of Otolaryngology, Head and Neck Surgery University of Yamanashi Chuo Japan.
Department of Otolaryngology-Head and Neck Surgery Kyoto Prefectural University of Medicine Kyoto Japan.
出版信息
Clin Case Rep. 2022 Jul 18;10(7):e6050. doi: 10.1002/ccr3.6050. eCollection 2022 Jul.
Metastatic intrathyroid thymic carcinoma (ITTC) is a rare cancer with no effective drugs for controlling. This case report has shown genomic and immune microenvironment profiles in metastatic ITTC and emphasized an immunosuppression via a PD-1/PD-L1 pathway, possibly strengthening the rationale for immune checkpoint blockade as a novel treatment.
转移性甲状腺内胸腺癌（ITTC）是一种罕见的癌症，目前尚无有效的控制药物。本病例报告展示了转移性ITTC的基因组和免疫微环境特征，并强调了通过PD-1/PD-L1途径的免疫抑制作用，这可能为免疫检查点阻断作为一种新的治疗方法提供了理论依据。
Zotero 插件