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病例报告:因局限性骨化性肌炎而无法像袋鼠一样跳跃。

Case Report: Unable to Jump Like a Kangaroo Due to Myositis Ossificans Circumscripta.

作者信息

Huenerfauth Enrice I, Molnár Viktor, Rosati Marco, Ciurkiewicz Malgorzata, Söbbeler Franz J, Harms Oliver, Hildebrandt Robert, Baumgärtner Wolfgang, Tipold Andrea, Volk Holger A, Nessler Jasmin

机构信息

Department of Small Animal Internal Medicine and Surgery, University of Veterinary Medicine Foundation, Hannover, Germany.

Hannover Adventure Zoo, Hannover, Germany.

出版信息

Front Vet Sci. 2022 Jul 4;9:886495. doi: 10.3389/fvets.2022.886495. eCollection 2022.

Abstract

A male 10-year-old captive red kangaroo () was presented with a chronic progressive pelvic limb lameness and reluctance to jump. The general examination revealed a palpable induration of the lumbar epaxial muscles. Magnetic resonance imaging performed under general anesthesia revealed bilateral almost symmetric, well-circumscribed mass lesions in superficial erector spinae muscles. The lesions had irregular to multilobulated appearance with hyper-, hypo-, and isointense areas in T2- and T1-weighted (w) sequences without contrast enhancement. On computed tomography, a peripheral rim of mineralization was apparent. Histopathological analysis of a muscle biopsy showed osseous trabeculae with rare clusters of chondrocytes indicating metaplasia of muscle tissue to bone. No indications of inflammation or malignancy were visible. The clinical, histopathological, and imaging workup of this case was consistent with . This disorder is particularly well-known among human professional athletes such as basketball players, where excessive, chronic-repetitive force or blunt trauma causes microtrauma to the musculature. Metaplasia of muscle tissue due to abnormal regeneration processes causes heterotopic ossification. The kangaroo's clinical signs improved with cyto-reductive surgery, cage rest, weight reduction, and meloxicam without further relapse.

摘要

一只10岁的圈养雄性红袋鼠出现慢性进行性后肢跛行且不愿跳跃。全身检查发现腰背部轴上肌有可触及的硬结。在全身麻醉下进行的磁共振成像显示,竖脊肌浅层有双侧几乎对称、边界清晰的肿块病变。这些病变在T2加权和T1加权序列中呈现不规则至多叶状外观,有高信号、低信号和等信号区,无强化。在计算机断层扫描中,可见周边有矿化边缘。肌肉活检的组织病理学分析显示有骨小梁,伴有罕见的软骨细胞簇,表明肌肉组织化生为骨。未见炎症或恶性迹象。该病例的临床、组织病理学和影像学检查结果与[具体病症]一致。这种病症在篮球运动员等人类职业运动员中尤为常见,过度的慢性重复性力量或钝性创伤会导致肌肉组织微创伤。异常再生过程导致的肌肉组织化生会引起异位骨化。袋鼠的临床症状通过减瘤手术、笼养休息、体重减轻和使用美洛昔康得到改善,未进一步复发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39b8/9295721/86a198749bd5/fvets-09-886495-g0001.jpg

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