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一种用于程序性化学免疫疗法的双响应阿霉素-吲哚莫德偶联物。

A dual-responsive doxorubicin-indoximod conjugate for programmed chemoimmunotherapy.

作者信息

Yang Zhaoxuan, Huang Jiaqi, Lin Yaying, Luo Xiangjie, Lin Haojin, Lin Hongyu, Gao Jinhao

机构信息

Fujian Provincial Key Laboratory of Chemical Biology, The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University Xiamen 361005 China China

出版信息

RSC Chem Biol. 2022 May 30;3(7):853-858. doi: 10.1039/d1cb00257k. eCollection 2022 Jul 6.

DOI:10.1039/d1cb00257k
PMID:35866166
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9257650/
Abstract

Herein we report a dual-responsive doxorubicin-indoximod conjugate (DOXIND) for programmed chemoimmunotherapy. This conjugate is able to release doxorubicin and indoximod upon exposure to appropriate stimuli for synergistic chemotherapy and immunotherapy, respectively. We demonstrate its promoting effects on immune response and inhibiting effects on tumor growth through a series of and experiments.

摘要

在此，我们报道了一种用于程序性化学免疫疗法的双响应阿霉素-吲哚莫德共轭物（DOXIND）。该共轭物在分别暴露于适当刺激时能够释放阿霉素和吲哚莫德，以分别进行协同化疗和免疫疗法。我们通过一系列实验证明了其对免疫反应的促进作用和对肿瘤生长的抑制作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/752a/9257650/27c878059007/d1cb00257k-p1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/752a/9257650/7cabc7be5ffb/d1cb00257k-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/752a/9257650/0ff011621738/d1cb00257k-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/752a/9257650/0c8342ff80bd/d1cb00257k-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/752a/9257650/a4e102e5e7a4/d1cb00257k-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/752a/9257650/6715f0f451f3/d1cb00257k-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/752a/9257650/27c878059007/d1cb00257k-p1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/752a/9257650/7cabc7be5ffb/d1cb00257k-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/752a/9257650/0ff011621738/d1cb00257k-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/752a/9257650/0c8342ff80bd/d1cb00257k-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/752a/9257650/a4e102e5e7a4/d1cb00257k-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/752a/9257650/6715f0f451f3/d1cb00257k-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/752a/9257650/27c878059007/d1cb00257k-p1.jpg

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ACS Chem Biol. 2022 Apr 15;17(4):762-767. doi: 10.1021/acschembio.1c00933. Epub 2022 Mar 14.
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Clin Transl Med. 2021 Jun;11(6):e456. doi: 10.1002/ctm2.456.
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