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肥胖患者行减重手术时采用个体化呼气末正压通气联合或不联合肺复张手法。

Individualized positive end-expiratory pressure with and without recruitment maneuvers in obese patients during bariatric surgery.

机构信息

Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China.

Department of Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

出版信息

Kaohsiung J Med Sci. 2022 Sep;38(9):858-868. doi: 10.1002/kjm2.12576. Epub 2022 Jul 22.

Abstract

This study aimed to determine whether regular recruitment maneuvers (RMs) are essential for obese patients (OPs) undergoing elective laparoscopic bariatric surgery (LBS) during intraoperative ventilation with individualized positive end-expiratory pressure (PEEP). Patients were randomly assigned to two arms: the RM + PEEP arm consisted of individualized PEEP titrated by electrical impedance tomography (EIT) with two regular RMs and the PEEP arm consisted of individualized PEEP titrated by EIT without additional RMs. For these two arms together, EIT-guided PEEP varied among individuals. The partial pressure of oxygen in arterial blood to fractional inspired oxygen (PaO /FiO ) ratio in the RM + PEEP arm was higher than that in the PEEP arm at 1 h after pneumoperitoneum (p = 0.024) and at the end of surgery (p = 0.035). There was no great difference in the PaO /FiO ratio between these two arms when measured 5 min prior to postanesthesia care unit (PACU) departure and on postoperative day 1. Compared with the PEEP arm, patients in the RM + PEEP arm had significantly higher intraoperative dynamic respiratory system compliance (p < 0.001) but consumed more vasopressors (p = 0.036). Postoperative pulmonary complications occurred in 1 of 29 patients in the RM + PEEP arm compared with 2 of 31 patients in the PEEP arm. Regular lung RMs can improve intraoperative oxygenation and respiratory system compliance among OPs undergoing LBS with EIT-guided individual PEEP. However, the improvement might disappear before leaving the PACU, and regular RMs resulted in more vasopressor consumption.

摘要

本研究旨在确定在接受术中通气时,肥胖患者(OP)是否需要常规肺复张(RM),通气时采用个体化呼气末正压(PEEP)。患者被随机分为两组:RM+PEEP 组采用 EIT 滴定个体化 PEEP,并进行两次常规 RM;PEEP 组则采用 EIT 滴定个体化 PEEP,不进行额外的 RM。这两组患者的 EIT 指导 PEEP 因人而异。RM+PEEP 组的动脉血氧分压与吸入氧分数(PaO /FiO )比值在气腹后 1 小时(p=0.024)和手术结束时(p=0.035)高于 PEEP 组。在 PACU 离开前 5 分钟和术后第 1 天,两组患者的 PaO /FiO 比值无明显差异。与 PEEP 组相比,RM+PEEP 组患者的术中动态呼吸系统顺应性显著更高(p<0.001),但血管加压素用量更多(p=0.036)。RM+PEEP 组有 1 例患者(3.4%)发生术后肺部并发症,PEEP 组有 2 例(6.5%)。EIT 指导的个体化 PEEP 可改善肥胖患者行腹腔镜减重手术的术中氧合和呼吸系统顺应性。但在离开 PACU 之前,这种改善可能会消失,并且常规 RM 会导致更多的血管加压素使用。

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