State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral Implantology, West China Hospital of Stomatology, Sichuan University, 610041 Chengdu, Sichuan, China.
Front Biosci (Landmark Ed). 2022 Jun 27;27(7):205. doi: 10.31083/j.fbl2707205.
Liquid biopsy has advantages over traditional biopsy, which cannot determine tumor dynamics. As a noninvasive and precise test, liquid biopsy detects biomarkers that carry information on tumor progression and has undergone tremendous development in recent years. Exosome detection is one of the methods of liquid biopsy. Radiotherapy affects the release of exosomes and intercellular communication. Based on the properties, extractability, and detectability of exosomes, key exosomal cargoes after tumor radiotherapy can be used as biomarkers for tumor prognosis. Exosomes after tumor radiotherapy can be used for liquid biopsy. The main applications include (1) predicting radiotherapy efficacy, (2) predicting tumor prognosis, and (3) optimizing the regimen of tumor treatment. This review provides further research directions for liquid biopsy after tumor radiotherapy.
液体活检相较于传统活检具有优势，因为传统活检无法确定肿瘤的动态变化。液体活检是一种非侵入性且精确的检测方法，可检测到携带肿瘤进展信息的生物标志物，近年来得到了迅猛发展。外泌体检测是液体活检的方法之一。放射治疗会影响外泌体的释放和细胞间的通讯。基于外泌体的特性、可提取性和可检测性，肿瘤放疗后的关键外泌体货物可作为肿瘤预后的生物标志物。肿瘤放疗后的外泌体可用于液体活检。主要应用包括（1）预测放疗疗效，（2）预测肿瘤预后，以及（3）优化肿瘤治疗方案。本文综述为肿瘤放疗后的液体活检提供了进一步的研究方向。
