Dhar V, Stark R, Kraulis I, Murphy B E
J Steroid Biochem. 1987 May;26(5):577-80. doi: 10.1016/0022-4731(87)90010-0.
While progesterone metabolites have long been known to be potent anesthetics in pharmacological doses, there is no available information as to their effects on behaviour at physiological levels. In this study, 5 alpha- and 5 beta-pregnanediones in silastic capsules were implanted in ovariectomized rats. Approximately 4 mg/kg/day was absorbed over a 24-day period. Rats receiving 5 beta-pregnanedione had decreased motor activity (58% control, P less than or equal to 0.001) while those receiving the 5 alpha-isomer had increased activity (143% control, P = 0.01). These studies suggest that these progesterone metabolites may be responsible for some behavioural changes.
虽然长期以来人们都知道孕酮代谢物在药理剂量下是强效麻醉剂，但关于它们在生理水平上对行为的影响却没有可用信息。在本研究中，将含有5α-和5β-孕烷二酮的硅橡胶胶囊植入去卵巢大鼠体内。在24天的时间里，大约每天吸收4mg/kg。接受5β-孕烷二酮的大鼠运动活动减少（为对照组的58%，P≤0.001），而接受5α-异构体的大鼠活动增加（为对照组的143%，P = 0.01）。这些研究表明，这些孕酮代谢物可能是某些行为变化的原因。
