Department of Nuclear Medicine, the First Affiliated Hospital of Zhengzhou University, Henan Medical Key Laboratory of Molecular Imaging, Zhengzhou City, Henan Province, China.
Medicine (Baltimore). 2022 Jul 22;101(29):e29564. doi: 10.1097/MD.0000000000029564.
To investigate the characteristics and factors that impact the prognosis of Ewing sarcoma/peripheral primitive neuroectodermal tumor (ES/pPNET) patients. We retrospectively analyzed ES/pPNET patients diagnosed at our hospital from January 2011 to December 2020. We used 1-way analysis of variance to investigate whether the age differences between different subgroups were statistically significant and used the Kaplan-Meier method and Cox regression model for the survival analysis. Of the 67 included patients, 13 had central nervous system PNET, and 54 had ES/pPNET. The median survival time of the 54 ES/pPNET patients was 18 months; the 1-year, 3-year and 5-year progression-free survival rates were 37.0% and 9.3% and 1.9%, respectively; and the 1-year, 3-year and 5-year overall survival (OS) rates were 66.7%, 27.8%, and 7.4%, respectively. The 1-way analysis of variance results showed no statistically significant age difference between the different subgroups (P = .127 between the central nervous system PNET and ES/pPNET groups, P = .764 between different subgroups within the ES/pPNET group). The univariate survival analysis showed that metastasis at diagnosis and the treatment method were independent factors affecting the OS rate of ES/pPNET patient (P = .003 and 0.000, respectively). The multivariate survival analysis also showed that the treatment method and metastasis at diagnosis were related factors affecting OS (P = .025 and 0.001, respectively). The prognosis of patients with primitive neuroectodermal tumors is poor. The treatment method and metastasis at the time of diagnosis influences ES/pPNET patient survival time, but there is no significant tumor site-dependent correlation with patient age or sex.
为了探讨尤文肉瘤/外周原始神经外胚层肿瘤（ES/pPNET）患者的特征和影响预后的因素，我们对 2011 年 1 月至 2020 年 12 月在我院诊断的 ES/pPNET 患者进行了回顾性分析。我们使用单因素方差分析来研究不同亚组之间的年龄差异是否有统计学意义，并使用 Kaplan-Meier 方法和 Cox 回归模型进行生存分析。在 67 例纳入的患者中，13 例患有中枢神经系统 PNET，54 例患有 ES/pPNET。54 例 ES/pPNET 患者的中位生存时间为 18 个月；1 年、3 年和 5 年无进展生存率分别为 37.0%、9.3%和 1.9%；1 年、3 年和 5 年总生存率（OS）分别为 66.7%、27.8%和 7.4%。单因素方差分析结果显示，不同亚组之间的年龄差异无统计学意义（中枢神经系统 PNET 组与 ES/pPNET 组之间的 P =.127，ES/pPNET 组内不同亚组之间的 P =.764）。单因素生存分析显示，诊断时转移和治疗方法是影响 ES/pPNET 患者 OS 率的独立因素（P =.003 和 0.000）。多因素生存分析也显示，治疗方法和诊断时转移是影响 OS 的相关因素（P =.025 和 0.001）。原始神经外胚层肿瘤患者的预后较差。治疗方法和诊断时转移影响 ES/pPNET 患者的生存时间，但与患者年龄或性别无明显的肿瘤部位相关性。
