Ackerman Leah H, Toonder Madison, Bosch Sarah, Semenova Varvara B, Spicer Timothy P, Alas Oscar, Thorsen Lily S, Menoyo Aitor Gallestegui, Stevenson Valentina B, Gutti Jishnu Rao, Saavedra Paulo Vilar, Nance Rebecca, Sahay Bakash, Hery Gabriela P, Chan Ann M, Salute Marc E, Bensilmane Nesrine, Vega Virneliz Fernandez, Milner Rowan J
Department of Small Animal Clinical Sciences, University of Florida College of Veterinary Medicine, Gainesville, Florida, USA.
Department of Molecular Medicine, The Herbert Wertheim University of Florida Scripps Institute, Jupiter, Florida, USA.
J Vet Intern Med. 2025 Mar-Apr;39(2):e70050. doi: 10.1111/jvim.70050.
Peripheral primitive neuroectodermal tumor (pPNET) is a very rare, highly malignant tumor encountered in young dogs, with only four necropsy cases in the veterinary literature. A 1.5-year-old male intact French Bulldog presented for evaluation of progressive left forelimb lameness and ipsilateral Horner's syndrome. Whole body computed tomography identified a 12 cm mediastinal mass with extension into the vertebral canal and multifocal metastatic lesions. Histological and immunohistochemical results were consistent with a pPNET. Chemotherapy, radiation therapy, immunotherapy, and targeted therapy were administered. Precision-based tumor testing, including DNA sequencing and chemosensitivity assays, were performed to guide systemic treatment recommendations. A partial remission was observed 3.5 months from presentation based on imaging and improved clinical status. After 7 months of treatment, diffuse metastatic disease, including intracranial spread, was observed and the dog was euthanized.
外周原始神经外胚层肿瘤（pPNET）是一种在幼犬中罕见的高度恶性肿瘤，兽医文献中仅有4例尸检病例。一只1.5岁的未绝育法国斗牛犬前来评估进行性左前肢跛行和同侧霍纳综合征。全身计算机断层扫描发现一个12厘米的纵隔肿块，延伸至椎管并伴有多灶性转移病变。组织学和免疫组化结果与pPNET一致。给予了化疗、放疗、免疫治疗和靶向治疗。进行了基于精准的肿瘤检测，包括DNA测序和化疗敏感性测定，以指导全身治疗建议。根据影像学检查和改善的临床状况，从就诊起3.5个月观察到部分缓解。治疗7个月后，观察到包括颅内扩散在内的弥漫性转移性疾病，该犬被实施安乐死。
