Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
Center for Radiology and Radiation Oncology, Kobe University Hospital, Kobe, Japan.
Medicine (Baltimore). 2022 Jul 22;101(29):e29511. doi: 10.1097/MD.0000000000029511.
Scarring and pain are postoperative complications in patients after head and neck cancer treatment; however, there is no effective treatment. These complications are affected by local blood flow disorders, and it is well known that the transcutaneous application of carbon dioxide (CO2) improves local blood flow. Previously, we have shown that the transcutaneous application of carbon dioxide causes absorption of CO2 and increase the oxygen (O2) pressure in the treated tissue; it is expected that the application of CO2 may reduce scarring and pain caused by cancer treatment. We newly introduced the CO2 paste as a new CO2 application method, which does not need to use CO2 gas directly. In this study, we aimed to apply of CO2 paste to healthy people and to investigate its usefulness, safety and feasibility by analysing the increase in blood flow and frequency of adverse events.
We applied carbon dioxide paste to skin over the sternocleidomastoid and gastrocnemius muscles of eight healthy volunteers. The changes in blood flow before and after the CO2 paste application using dynamic MRI, and changes in the vital signs were evaluated.
In the neck area and middle layer of the lower leg, the signal intensity (SI) significantly increased 60 seconds after application. In the surface layer of the lower leg, the SI was significantly increased 60 and 300 seconds after paste application. Although mild heat was noted after the paste application, no obvious adverse events occurred.
We demonstrated the increase in SI by dynamic MRI at the site of the carbon dioxide paste application, which indicates the paste application is effective in improving the blood flow.
在头颈部癌症治疗后，患者会出现瘢痕和疼痛等术后并发症，但目前尚无有效的治疗方法。这些并发症与局部血流紊乱有关，众所周知，二氧化碳（CO2）经皮应用可改善局部血流。此前，我们已经表明，CO2 的经皮应用会导致 CO2 吸收并增加治疗组织中的氧气（O2）压力；预计 CO2 的应用可能会减轻癌症治疗引起的瘢痕和疼痛。我们新引入了 CO2 糊剂作为一种新的 CO2 应用方法，无需直接使用 CO2 气体。在这项研究中，我们旨在将 CO2 糊剂应用于健康人群，并通过分析血流量的增加和不良事件的发生频率来评估其有用性、安全性和可行性。
我们将二氧化碳糊剂应用于 8 名健康志愿者的胸锁乳突肌和腓肠肌的皮肤表面。使用动态 MRI 评估 CO2 糊剂应用前后血流量的变化，以及生命体征的变化。
在颈部区域和小腿中层，应用后 60 秒信号强度（SI）显著增加。在小腿表面层，应用糊剂后 60 和 300 秒时 SI 显著增加。虽然糊剂应用后有轻微发热，但未发生明显不良事件。
我们通过 CO2 糊剂应用部位的动态 MRI 显示 SI 增加，表明糊剂应用可有效改善血流。
