Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Department of pharmacy, Wuhan Fourth Hospital; Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Medicine (Baltimore). 2022 Jul 22;101(29):e29512. doi: 10.1097/MD.0000000000029512.
Elevated circulating concentrations of the gut metabolite, trimethylamine N-oxide (TMAO), were found in patients who experienced stroke. However, it has not been reported whether a high level of TMAO is associated with a significantly increased risk of stroke. This study aimed to review the available scientific evidence about the relationship between TMAO levels and the risk of stroke in a dose-response meta-analysis.
The PubMed, Embase, Cochrane library, and China National Knowledge Infrastructure databases were searched for studies starting from September 1996 to December 2020. Nine studies including 4402 subjects were reviewed in this study.
The results of meta-analysis showed that high levels of circulating TMAO were associated with an increased risk of stroke in patients in the random-effects model (odds ratio [OR], 1.64; 95% confidence interval [CI], 1.12-2.41; P = 0.047). The OR for the prevalence of stroke increased by 48% per 5-μmol/L increment (OR, 1.05; 95% CI, 1.16-1.78; P < 0.001) and by 132% per 10-μmol/L increment (OR, 2.32; 95% CI, 1.38-3.86; P < 0.001) in circulating TMAO concentration according to the dose-response meta-analysis.
There was a significant association between higher plasma TMAO concentrations and the risk of stroke. Further in-depth studies are warranted to validate this interaction and explore potential mechanisms.
患有中风的患者其循环血液中肠道代谢产物三甲胺 N-氧化物（TMAO）的浓度升高。然而，目前尚未有报道表明 TMAO 水平升高与中风风险显著增加之间存在关联。本研究旨在通过剂量反应荟萃分析来回顾 TMAO 水平与中风风险之间关系的现有科学证据。
从 1996 年 9 月至 2020 年 12 月，我们检索了 PubMed、Embase、Cochrane 图书馆和中国国家知识基础设施数据库中的研究。本研究共纳入了 9 项研究，共计 4402 例患者。
荟萃分析结果表明，在随机效应模型中，循环 TMAO 水平升高与患者中风风险增加相关（比值比 [OR]，1.64；95%置信区间 [CI]，1.12-2.41；P = 0.047）。每增加 5-μmol/L，中风患病率的 OR 增加 48%（OR，1.05；95% CI，1.16-1.78；P < 0.001），每增加 10-μmol/L，OR 增加 132%（OR，2.32；95% CI，1.38-3.86；P < 0.001）。
较高的血浆 TMAO 浓度与中风风险之间存在显著关联。需要进一步的深入研究来验证这种相互作用并探索潜在机制。
