Research Group BIOMIC (Biosynthesis of Antitumor Molecules), Departamento de Biología Funcional, Área de Microbiología, Universidad de Oviedo, 33006 Oviedo, Spain.
IUOPA (Instituto Universitario de Oncología del Principado de Asturias), 33006 Oviedo, Spain.
Int J Mol Sci. 2024 Sep 27;25(19):10397. doi: 10.3390/ijms251910397.
Cardiovascular disease is the main cause of mortality in industrialized countries, with over 500 million people affected worldwide. In this work, the roles of low-molecular-weight metabolites originating from the gut microbiome, such as short-chain fatty acids, hydrogen sulfide, trimethylamine, phenylacetic acid, secondary bile acids, indoles, different gases, neurotransmitters, vitamins, and complex lipids, are discussed in relation to their CVD-promoting or preventing activities. Molecules of mixed microbial and human hepatic origin, such as trimethylamine N-oxide and phenylacetylglutamine, are also presented. Finally, dietary agents with cardioprotective effects, such as probiotics, prebiotics, mono- and poly-unsaturated fatty acids, carotenoids, and polyphenols, are also discussed. A special emphasis is given to their gut microbiota-modulating properties.
心血管疾病是工业化国家主要的死亡原因，全球有超过 5 亿人受到影响。在这项工作中，讨论了源自肠道微生物组的低分子量代谢物（如短链脂肪酸、硫化氢、三甲胺、苯乙酸、次级胆汁酸、吲哚、不同气体、神经递质、维生素和复合脂质）在促进或预防 CVD 方面的作用。还介绍了一些混合微生物和人类肝脏来源的分子，如三甲胺 N-氧化物和苯乙酰谷氨酰胺。最后，还讨论了具有心脏保护作用的膳食因子，如益生菌、益生元、单不饱和和多不饱和脂肪酸、类胡萝卜素和多酚。特别强调了它们对肠道微生物组的调节作用。
