WNT 型髓母细胞瘤的困境：我们能降多低？
WNT Medulloblastoma Limbo: How Low Can We Go?
机构信息
Department of Pediatric Oncology, Hematology, and Clinical Immunology, University Hospital Düsseldorf, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
Institute of Neuropathology, University Hospital Düsseldorf, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
出版信息
Clin Cancer Res. 2022 Oct 3;28(19):4161-4163. doi: 10.1158/1078-0432.CCR-22-1780.
Survival rates for average-risk medulloblastoma exceed 80%; however, long-term sequelae are substantial. A study from Mumbai, India evaluated the role of omission of craniospinal irradiation. Albeit unsuccessful, this study raises the crucial question of how low therapy can be safely de-escalated with the intent of improving quality of survival. See related article by Gupta et al., p. 4180.
平均风险型髓母细胞瘤的存活率超过 80%；然而，长期后遗症显著。印度孟买的一项研究评估了省略颅脊髓照射的作用。尽管该研究失败了，但它提出了一个关键问题，即如何在不降低安全性的情况下安全地降低治疗强度，从而提高生存质量。见古普塔等人的相关文章，第 4180 页。
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