奥美沙坦可改善腹膜炎诱导脓毒症大鼠的器官损伤和死亡率。
Olmesartan Ameliorates Organ Injury and Mortality in Rats With Peritonitis-Induced Sepsis.
机构信息
Department of Anesthesiology, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Anesthesiology, Taipei Veterans General Hospital, Taipei, Taiwan.
Division of Pulmonary and Critical Care, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
出版信息
J Surg Res. 2022 Nov;279:526-532. doi: 10.1016/j.jss.2022.05.034. Epub 2022 Jul 19.
INTRODUCTION
Sepsis and related complications lead to high morbidity and mortality in humans and animals. Olmesartan medoxomil (OLM), a nonpeptide angiotensin II type 1 receptor blocker, has antiinflammatory and antioxidative effects in various experimental animal models. The present study aimed to investigate whether OLM protects against sepsis in a clinically relevant model of polymicrobial sepsis induced by cecal ligation and puncture (CLP).
METHODS
Sepsis was induced by CLP in anesthetized rats. OLM was administered intraperitoneally 3 h after CLP onset. Hemodynamic, biochemical, and inflammatory parameters were analyzed.
RESULTS
The administration of OLM in CLP rats significantly improved their survival rate. Moreover, OLM mitigated CLP-induced hypotension and organ injury (indicated by biochemical parameters), but not tachycardia. OLM significantly reduced the plasma levels of interleukin-6 and nitric oxide.
CONCLUSIONS
OLM markedly attenuated CLP-induced hypotension and organ injury, and hence improved survival by inhibiting the inflammatory response and nitrosative stress in this clinically relevant model of sepsis.
简介
败血症及相关并发症可导致人和动物的高发病率和死亡率。奥美沙坦酯（OLM），一种非肽类血管紧张素 II 型 1 型受体阻滞剂，在各种实验动物模型中具有抗炎和抗氧化作用。本研究旨在探讨奥美沙坦酯是否可以通过盲肠结扎穿孔（CLP）诱导的多微生物败血症的临床相关模型来预防败血症。
方法
在麻醉大鼠中通过 CLP 诱导败血症。在 CLP 发作后 3 小时通过腹腔内给药 OLM。分析血流动力学、生化和炎症参数。
结果
在 CLP 大鼠中给予 OLM 可显著提高其生存率。此外，OLM 减轻了 CLP 引起的低血压和器官损伤（通过生化参数表明），但没有心动过速。OLM 显著降低了血浆中白细胞介素-6 和一氧化氮的水平。
结论
在这种临床相关的败血症模型中，奥美沙坦酯显著减轻了 CLP 引起的低血压和器官损伤，并通过抑制炎症反应和硝化应激而显著改善了生存率。
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