KAT7 通过促进 YAP1 的激活促进胃癌的进展。
KAT7 promoted gastric cancer progression through promoting YAP1 activation.
机构信息
Department of Gastroenterology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi province 710068, China.
Department of Gastroenterology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi province 710068, China.
出版信息
Pathol Res Pract. 2022 Sep;237:154020. doi: 10.1016/j.prp.2022.154020. Epub 2022 Jul 14.
Lysine acetyltransferase 7 (KAT7) was upregulated in gastric cancer (GC) patient tissues, and associated with poor prognosis and metastasis. However, its specific role in GC remains unclear. This study aimed to annotate the role of KAT7 in GC cells. The results showed that the overexpression of KAT7 promoted cell growth, migration, and invasion, while KAT7 inhibition has the opposite effect. Besides, KAT7 participated in cell cycle phase distribution and epithelial-mesenchymal transition (EMT) process of GC cells. In addition, KAT7 promoted the transcription and nuclear translocation of Yes-associated protein 1 (YAP1) in MKN45 cells. Silence of YAP1 partly reversed the promoting effect of KAT7 on GC cells progression. In summary, this study indicates that KAT7 promoted GC cells progression through promoting YAP1 activation, contributes to understand the specific role of KAT7 in GC.
赖氨酸乙酰转移酶 7（KAT7）在胃癌（GC）患者组织中上调，与预后不良和转移有关。然而，其在 GC 中的具体作用尚不清楚。本研究旨在注释 KAT7 在 GC 细胞中的作用。结果表明，KAT7 的过表达促进了细胞的生长、迁移和侵袭，而 KAT7 的抑制则产生相反的效果。此外，KAT7 参与了 GC 细胞的细胞周期分布和上皮-间充质转化（EMT）过程。此外，KAT7 促进了 YAP1 在 MKN45 细胞中的转录和核易位。沉默 YAP1 部分逆转了 KAT7 对 GC 细胞进展的促进作用。综上所述，本研究表明，KAT7 通过促进 YAP1 的激活来促进 GC 细胞的进展，有助于理解 KAT7 在 GC 中的具体作用。
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