Division of Gastroenterology and Hepatology, Digestive Disease Institute, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China.
Department of Gastroenterology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, 250013, China.
Biochem Biophys Res Commun. 2022 Oct 1;623:23-31. doi: 10.1016/j.bbrc.2022.07.018. Epub 2022 Jul 14.
In-depth knowledge of liver regeneration could facilitate the development of therapies for liver injury and liver failure. As a member of the homeobox superfamily, HOXA13 plays an important role in regulating tumorigenesis and development. However, the exact role of HOXA13 in liver regeneration remains unclear. In this study, we confirmed that HOXA13 promotes hepatocyte proliferation both in vivo and in vitro. HOXA13 was upregulated during liver regeneration, and its overexpression further accelerated hepatocyte proliferation and liver function recovery during liver regeneration. Furthermore, we found that HOXA13 promoted hepatocyte proliferation and liver regeneration by upregulating bone morphogenetic protein-7 (BMP-7) mRNA. These findings provide a new potential target for the treatment of liver failure.
深入了解肝脏再生机制有助于开发肝脏损伤和肝衰竭的治疗方法。作为同源盒超家族的一员，HOXA13 在肿瘤发生和发展中起着重要作用。然而，HOXA13 在肝脏再生中的确切作用尚不清楚。在这项研究中，我们证实 HOXA13 可促进体内和体外的肝细胞增殖。在肝脏再生过程中，HOXA13 的表达上调，其过表达进一步加速了肝细胞增殖和肝功能恢复。此外，我们发现 HOXA13 通过上调骨形态发生蛋白-7（BMP-7）mRNA 促进肝细胞增殖和肝脏再生。这些发现为治疗肝衰竭提供了一个新的潜在靶点。
